Association between XRCC3 p.Thr241Met polymorphism and risk of glioma: a systematic review and meta-analysis

Shing Cheng Tan*, Teck Yew Low, Hafiz Muhammad Jafar Hussain, Mohamad Ayub Khan Sharzehan, Hilary Sito, Hamed Kord-Varkaneh, Md Asiful Islam

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

97 Downloads (Pure)

Abstract

Background: The XRCC3 p.Thr241Met (rs861539) polymorphism has been extensively studied for its association with glioma risk, but results remain conflicting. Therefore, we performed a systematic review and meta-analysis to resolve this inconsistency.

Methods: Studies published up to June 10, 2022, were searched in PubMed, Web of Science, Scopus, VIP, Wanfang, and China National Knowledge Infrastructure databases and screened for eligibility. Then, the combined odds ratio (OR) of the included studies was estimated based on five genetic models, i.e., homozygous (Met/Met vs. Thr/Thr), heterozygous (Thr/Met vs. Thr/Thr), dominant (Thr/Met + Met/Met vs. Thr/Thr), recessive (Met/Met vs. Thr/Thr + Thr/ Met) and allele (Met vs. Thr). The study protocol was preregistered at PROSPERO (registration number: CRD42021235704).

Results: Overall, our meta-analysis of 14 eligible studies involving 12,905 subjects showed that the p.Thr241Met polymorphism was significantly associated with increased glioma risk in both homozygous and recessive models (homozygous, OR = 1.381, 95% CI = 1.081–1.764, P = 0.010; recessive, OR = 1.305, 95% CI = 1.140–1.493, P<0.001). Subgroup analyses by ethnicity also revealed a statistically significant association under the two aforementioned genetic models, but only in the Asian population and not in Caucasians (P>0.05).

Conclusion: We demonstrated that the XRCC3 p.Thr241Met polymorphism is associated with an increased risk of glioma only in the homozygous and recessive models.

Original languageEnglish
Article numbere0276313
Number of pages15
JournalPLoS ONE
Volume17
Issue number10
DOIs
Publication statusPublished - 20 Oct 2022

Bibliographical note

Funding Information:
Research in SCT’s laboratory is supported by the Research University Grant of Universiti Kebangsaan Malaysia (No. GUP-2020-076), the Fundamental Research Grant Scheme of the Ministry of Higher Education, Malaysia (No. FRGS/1/2019/SKK08/UKM/02/9), and the Higher Institution Center of Excellence (HICoE) grant of the Ministry of Higher Education, Malaysia (No. AKU49). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of this manuscript. The authors thank Academic Proofreading (https://www.academicproofreading.uk) for English language editing.

Publisher Copyright:
© 2022 Tan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Keywords

  • gene
  • systematic review
  • meta-analysis

ASJC Scopus subject areas

  • General
  • Genetics(clinical)

Fingerprint

Dive into the research topics of 'Association between XRCC3 p.Thr241Met polymorphism and risk of glioma: a systematic review and meta-analysis'. Together they form a unique fingerprint.

Cite this