Association between serum free T4 concentration and atrial fibrillation

Michael Gammage, James Parle, Roger Holder, Lesley Roberts, Frederick Hobbs, Sue Wilson, Michael Sheppard, Jayne Franklyn

Research output: Contribution to journalArticle

162 Citations (Scopus)


BACKGROUND: Previous studies have suggested that minor changes in thyroid function are associated with risk of atrial fibrillation (AF). Our objective was to determine the relationship between thyroid function and presence of atrial fibrillation (AF) in older subjects. METHODS: A population-based study of 5860 subjects 65 years and older, which excluded those being treated for thyroid dysfunction and those with previous hyperthyroidism. Main outcome measures included tests of thyroid function (serum free thyroxine [T(4)] and thyrotropin [TSH]) and the presence of AF on resting electrocardiogram. RESULTS: Fourteen subjects (0.2%) had previously undiagnosed overt hyperthyroidism and 126 (2.2%), subclinical hyperthyroidism; 5519 (94.4%) were euthyroid; and 167 (2.9%) had subclinical hypothyroidism and 23 (0.4%), overt hypothyroidism. The prevalence of AF in the whole cohort was 6.6% in men and 3.1% in women (odds ratio, 2.23; P
Original languageEnglish
Pages (from-to)928-934
Number of pages7
JournalArchives of Internal Medicine
Issue number9
Publication statusPublished - 14 May 2007


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