Association between loss of Y chromosome and poor prognosis in male head and neck squamous cell carcinoma

Robert Hollows; Wenbin Wei; Jean-Baptiste Cazier; Hisham Mehanna; Gabriella Parry; Graham Halford; Paul Murray

doi:10.1002/hed.25537

Association between loss of Y chromosome and poor prognosis in male head and neck squamous cell carcinoma

Robert Hollows, Wenbin Wei, Jean-Baptiste Cazier, Hisham Mehanna, Gabriella Parry, Graham Halford, Paul Murray

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

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Abstract

BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is more prevalent in men than women and this disparity cannot be fully explained by known risk factors. Recent studies have shown that loss of Y chromosome (LoY) confers an increased risk of solid cancer and reduces life expectancy in men.

METHODS: Using publicly available data from The Cancer Genome Atlas, we investigated the prevalence of LoY and its association with clinicopathological features in male HNSCC.

RESULTS: LoY was detectable in around 25% of male HNSCC. Men with human papillomavirus-negative tumors exhibiting LoY experienced significantly worse overall survival than those with no LoY. Moreover, LoY tumors exhibited overexpression of genes involved in redox processes, including genes previously implicated in resistance to both radiotherapy and cisplatin-based chemotherapeutics.

CONCLUSION: LoY may be an indicator of poor prognosis in male HNSCC that is linked to the overexpression of genes associated with resistance to standard care therapies.

Original language	English
Pages (from-to)	993-1006
Number of pages	14
Journal	Head & Neck
Volume	41
Issue number	4
Early online date	23 Dec 2018
DOIs	https://doi.org/10.1002/hed.25537
Publication status	Published - 15 Mar 2019

Bibliographical note

Funding Information:
Medical Research Council, Grant/Award Number: 1608750

Publisher Copyright:
© 2018 The Authors. Head & Neck published by Wiley Periodicals, Inc.

Keywords

Y chromosome
aneuploidy
head and neck cancer
immune system
therapeutic resistance

ASJC Scopus subject areas

Otorhinolaryngology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hed.25537Licence: Creative Commons: Attribution (CC BY)

Robert_Hollows_et_al_Association_between_loss_of_Y_chromosome_Head_&_Neck_2018
Checked for eligibility: 09/01/2018
Final published version, 2.16 MBLicence: Creative Commons: Attribution (CC BY)

Cite this

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title = "Association between loss of Y chromosome and poor prognosis in male head and neck squamous cell carcinoma",

abstract = "BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is more prevalent in men than women and this disparity cannot be fully explained by known risk factors. Recent studies have shown that loss of Y chromosome (LoY) confers an increased risk of solid cancer and reduces life expectancy in men.METHODS: Using publicly available data from The Cancer Genome Atlas, we investigated the prevalence of LoY and its association with clinicopathological features in male HNSCC.RESULTS: LoY was detectable in around 25% of male HNSCC. Men with human papillomavirus-negative tumors exhibiting LoY experienced significantly worse overall survival than those with no LoY. Moreover, LoY tumors exhibited overexpression of genes involved in redox processes, including genes previously implicated in resistance to both radiotherapy and cisplatin-based chemotherapeutics.CONCLUSION: LoY may be an indicator of poor prognosis in male HNSCC that is linked to the overexpression of genes associated with resistance to standard care therapies.",

keywords = "Y chromosome, aneuploidy, head and neck cancer, immune system, therapeutic resistance",

author = "Robert Hollows and Wenbin Wei and Jean-Baptiste Cazier and Hisham Mehanna and Gabriella Parry and Graham Halford and Paul Murray",

note = "Funding Information: Medical Research Council, Grant/Award Number: 1608750 Publisher Copyright: {\textcopyright} 2018 The Authors. Head & Neck published by Wiley Periodicals, Inc.",

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doi = "10.1002/hed.25537",

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AU - Hollows, Robert

AU - Wei, Wenbin

AU - Cazier, Jean-Baptiste

AU - Mehanna, Hisham

AU - Parry, Gabriella

AU - Halford, Graham

AU - Murray, Paul

PY - 2019/3/15

Y1 - 2019/3/15

N2 - BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is more prevalent in men than women and this disparity cannot be fully explained by known risk factors. Recent studies have shown that loss of Y chromosome (LoY) confers an increased risk of solid cancer and reduces life expectancy in men.METHODS: Using publicly available data from The Cancer Genome Atlas, we investigated the prevalence of LoY and its association with clinicopathological features in male HNSCC.RESULTS: LoY was detectable in around 25% of male HNSCC. Men with human papillomavirus-negative tumors exhibiting LoY experienced significantly worse overall survival than those with no LoY. Moreover, LoY tumors exhibited overexpression of genes involved in redox processes, including genes previously implicated in resistance to both radiotherapy and cisplatin-based chemotherapeutics.CONCLUSION: LoY may be an indicator of poor prognosis in male HNSCC that is linked to the overexpression of genes associated with resistance to standard care therapies.

AB - BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is more prevalent in men than women and this disparity cannot be fully explained by known risk factors. Recent studies have shown that loss of Y chromosome (LoY) confers an increased risk of solid cancer and reduces life expectancy in men.METHODS: Using publicly available data from The Cancer Genome Atlas, we investigated the prevalence of LoY and its association with clinicopathological features in male HNSCC.RESULTS: LoY was detectable in around 25% of male HNSCC. Men with human papillomavirus-negative tumors exhibiting LoY experienced significantly worse overall survival than those with no LoY. Moreover, LoY tumors exhibited overexpression of genes involved in redox processes, including genes previously implicated in resistance to both radiotherapy and cisplatin-based chemotherapeutics.CONCLUSION: LoY may be an indicator of poor prognosis in male HNSCC that is linked to the overexpression of genes associated with resistance to standard care therapies.

KW - Y chromosome

KW - aneuploidy

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Association between loss of Y chromosome and poor prognosis in male head and neck squamous cell carcinoma

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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Cite this