Association between childhood maltreatment and atopy in the UK: a population based retrospective cohort study

Katrina Nash, Sonica Minhas, Nicholas Metheny, Krishna Gokhale, Julie Taylor, Caroline Bradbury-Jones, Siddhartha Bandyopadhyay, Krishnarajah Nirantharakumar, Joht Chandan*, Nicola Adderley*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background
Childhood maltreatment affects over one in three children worldwide and is associated with a substantial disease burden. This study explores the association between childhood maltreatment and the development of atopic disease.

Methods
We did a population-based retrospective matched open cohort study using participating general practices between 1st January 1995 and 30th September 2019. Read codes were utilised to identify patients exposed to childhood maltreatment (either suspected or confirmed) who were matched to up to four unexposed patients by age, sex, general practice, and Townsend deprivation quintile. Cox regression analysis was used to calculate adjusted (age, sex, Townsend deprivation quintile) hazard ratios (aHR) for development of atopy (asthma, atopic dermatitis, or allergic rhino conjunctivitis) during follow up in those without atopy at study entry.

Results
183,897 exposed patients were matched to 621,699 unexposed patients. During the follow up period, 18,555 patients (incidence rate (IR) 28.18 per 1000 person-years) in the exposed group developed atopic disease compared to the 68,368 (IR 23.58 per 1000 person-years) in the unexposed group, translating to an adjusted HR of 1.14 (95% CI 1.12–1.15). Notably, the risk of developing asthma was aHR 1.42 (95% CI 1.37–1.46). Associations were more pronounced in analyses restricted to females and confirmed cases of childhood maltreatment only.

Interpretation
Considering the substantial health burden associated with childhood maltreatment, it is important to implement public health policies aimed at enhancing: 1) detection and primary prevention of childhood maltreatment, 2) secondary and tertiary prevention interventions to reduce the burden of ill health associated with exposure to maltreatment and 3) clinical awareness of such associations and subsequent knowledge of management.
Original languageEnglish
Article number101730
Number of pages10
JournalEClinicalMedicine
Volume53
DOIs
Publication statusE-pub ahead of print - 14 Nov 2022

Keywords

  • Asthma
  • Rhino-conjunctivitis
  • Childhood maltreatment
  • Atopy
  • Atopic dermatitis

Fingerprint

Dive into the research topics of 'Association between childhood maltreatment and atopy in the UK: a population based retrospective cohort study'. Together they form a unique fingerprint.

Cite this