Assembly of the Mycobacterial Cell Wall

Monika Jankute; Jonathan A.g. Cox; James Harrison; Gurdyal S. Besra

doi:10.1146/annurev-micro-091014-104121

Assembly of the Mycobacterial Cell Wall

Monika Jankute, Jonathan A.g. Cox, James Harrison, Gurdyal S. Besra

Biosciences

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160 Citations (Scopus)

Abstract

Mycobacterium tuberculosis remains one of the most successful bacterial pathogens, claiming over 1.3 million lives worldwide in 2013. The emergence of multidrug-resistant and extensively drug-resistant isolates has prompted the need for new drugs and drug targets. M. tuberculosis possesses an unusual cell wall dominated by lipids and carbohydrates that provides a permeability barrier against hydrophilic drugs and is crucial for its survival and virulence. This large macromolecular structure, termed the mycolyl-arabinogalactan-peptidoglycan complex, and the phosphatidyl-myo-inositol-based lipoglycans are key features of the mycobacterial cell wall. Assembly of these cell wall components is an attractive target for the development of chemotherapeutics against tuberculosis. Herein, we focus on recent biochemical and molecular insights into these complex molecules of M. tuberculosis cell wall.

Original language	English
Pages (from-to)	405-423
Journal	Annual Review of Microbiology
Volume	69
Issue number	1
DOIs	https://doi.org/10.1146/annurev-micro-091014-104121
Publication status	Published - 15 Oct 2015

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10.1146/annurev-micro-091014-104121

http://www.annualreviews.org/doi/10.1146/annurev-micro-091014-104121

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DO - 10.1146/annurev-micro-091014-104121

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VL - 69

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EP - 423

JO - Annual Review of Microbiology

JF - Annual Review of Microbiology

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Assembly of the Mycobacterial Cell Wall

Abstract

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