Assembly and trafficking of P2X purinergic receptors (Review)

RD Murrell-Lagnado, Omar Qureshi

Research output: Contribution to journalReview article

37 Citations (Scopus)


P2X receptors are cation selective ion channels gated by the binding of extracellular ATP. Seven subtypes have been identified and they have widespread and overlapping distributions throughout the body. They form homo- and heterotrimeric complexes that differ in their functional properties and subcellular localization. They form part of larger signalling complexes, interacting with unrelated ion channels and other membrane and cytosolic proteins. Up- or down-regulation of their expression is associated with several disease states. This review aims to summarize recent work on the assembly and trafficking of this family of receptors.
Original languageEnglish
Pages (from-to)321-U15
JournalMolecular Membrane Biology
Issue number4
Publication statusPublished - 1 Jan 2008


  • assembly
  • trafficking
  • P2X purinergic receptors


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