Aryl-derivatized, water-soluble functionalized carbon nanotubes for biomedical applications

N. Karousis; H. Ali-Boucetta; K. Kostarelos; N. Tagmatarchis

doi:10.1016/j.mseb.2008.06.002

Aryl-derivatized, water-soluble functionalized carbon nanotubes for biomedical applications

N. Karousis, H. Ali-Boucetta, K. Kostarelos^*, N. Tagmatarchis

^*Corresponding author for this work

Pharmacy

Research output: Contribution to journal › Article › peer-review

Abstract

The functionalization of very-thin multi-walled carbon nanotubes (VT-MWNTs) with an aniline derivative, via the protocol of in situ generated aryl diazonium salts results, upon acidic deprotection of the terminal BOC group, on the formation of the water-soluble positively charged ammonium functionalized VT-MWNTs-NH₃⁺ material. The new materials have been structurally and morphologically characterized by infra-red (ATR-IR) spectroscopy and transmission electron microscopy (TEM). The quantitative calculation of the grafted aryl units onto the skeleton of VT-MWNTs has been estimated by thermogravimetric analysis (TGA), while the quantitative Kaiser test showed the amine group loaded onto VT-MWNTs-NH₃⁺ material. The aqueous solubility of this material has allowed the performance of some initial toxicological in vitro investigations.

Original language	English
Pages (from-to)	8-11
Number of pages	4
Journal	Materials Science and Engineering: B
Volume	152
Issue number	1-3
DOIs	https://doi.org/10.1016/j.mseb.2008.06.002
Publication status	Published - 25 Aug 2008

Keywords

Aryl diazonium salts
Biomedical applications
Functionalization
Nanotubes
Water soluble

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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10.1016/j.mseb.2008.06.002

Cite this

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title = "Aryl-derivatized, water-soluble functionalized carbon nanotubes for biomedical applications",

abstract = "The functionalization of very-thin multi-walled carbon nanotubes (VT-MWNTs) with an aniline derivative, via the protocol of in situ generated aryl diazonium salts results, upon acidic deprotection of the terminal BOC group, on the formation of the water-soluble positively charged ammonium functionalized VT-MWNTs-NH3+ material. The new materials have been structurally and morphologically characterized by infra-red (ATR-IR) spectroscopy and transmission electron microscopy (TEM). The quantitative calculation of the grafted aryl units onto the skeleton of VT-MWNTs has been estimated by thermogravimetric analysis (TGA), while the quantitative Kaiser test showed the amine group loaded onto VT-MWNTs-NH3+ material. The aqueous solubility of this material has allowed the performance of some initial toxicological in vitro investigations.",

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author = "N. Karousis and H. Ali-Boucetta and K. Kostarelos and N. Tagmatarchis",

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T1 - Aryl-derivatized, water-soluble functionalized carbon nanotubes for biomedical applications

AU - Karousis, N.

AU - Ali-Boucetta, H.

AU - Kostarelos, K.

AU - Tagmatarchis, N.

PY - 2008/8/25

Y1 - 2008/8/25

N2 - The functionalization of very-thin multi-walled carbon nanotubes (VT-MWNTs) with an aniline derivative, via the protocol of in situ generated aryl diazonium salts results, upon acidic deprotection of the terminal BOC group, on the formation of the water-soluble positively charged ammonium functionalized VT-MWNTs-NH3+ material. The new materials have been structurally and morphologically characterized by infra-red (ATR-IR) spectroscopy and transmission electron microscopy (TEM). The quantitative calculation of the grafted aryl units onto the skeleton of VT-MWNTs has been estimated by thermogravimetric analysis (TGA), while the quantitative Kaiser test showed the amine group loaded onto VT-MWNTs-NH3+ material. The aqueous solubility of this material has allowed the performance of some initial toxicological in vitro investigations.

AB - The functionalization of very-thin multi-walled carbon nanotubes (VT-MWNTs) with an aniline derivative, via the protocol of in situ generated aryl diazonium salts results, upon acidic deprotection of the terminal BOC group, on the formation of the water-soluble positively charged ammonium functionalized VT-MWNTs-NH3+ material. The new materials have been structurally and morphologically characterized by infra-red (ATR-IR) spectroscopy and transmission electron microscopy (TEM). The quantitative calculation of the grafted aryl units onto the skeleton of VT-MWNTs has been estimated by thermogravimetric analysis (TGA), while the quantitative Kaiser test showed the amine group loaded onto VT-MWNTs-NH3+ material. The aqueous solubility of this material has allowed the performance of some initial toxicological in vitro investigations.

KW - Aryl diazonium salts

KW - Biomedical applications

KW - Functionalization

KW - Nanotubes

KW - Water soluble

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ER -

Aryl-derivatized, water-soluble functionalized carbon nanotubes for biomedical applications

Abstract

Keywords

ASJC Scopus subject areas

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