Armadillo-repeat protein functions: questions for little creatures

R Tewari, E Bailes, KA Bunting, Juliet Coates

Research output: Contribution to journalReview articlepeer-review

159 Citations (Scopus)
1192 Downloads (Pure)

Abstract

Armadillo (ARK-repeat proteins form a large family with diverse and fundamental functions in many eukaryotes. ARM-repeat proteins have largely been characterised in multicellular organisms and much is known about how a subset of these proteins function. The structure of ARM-repeats allows proteins containing them to be functionally very versatile. Are the ARM-repeat proteins in 'little creatures' as multifunctional as their better-studied relatives? The time is now right to start analysing ARM-repeat proteins in these new systems to better understand their cell biology. Here, we review recent advances in understanding the many cellular roles of both well-known and novel ARM-repeat proteins.
Original languageEnglish
Pages (from-to)470-481
Number of pages12
JournalTrends in Cell Biology
Volume20
Issue number8
DOIs
Publication statusPublished - 1 Aug 2010

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