Arene ruthenium dithiolato-carborane complexes for boron neutron capture therapy (BNCT)

Isolda Romero Canelon, Ben Phoenix, Anaïs Pitto-Barry, Johanna Tran, Joan J. Soldevila-Barreda, Nigel Kirby, Stuart Green*, Peter J. Sadler, Nicolas P.E. Barry

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)
38 Downloads (Pure)

Abstract

We report the effect of low-energy thermal neutron irradiation on the antiproliferative activities of a highly hydrophobic organometallic arene ruthenium dithiolato-carborane complex [Ru(p-cymene) (1,2-dicarba-closo-dodecarborane-1,2-dithiolato)] (1), and of its formulation in Pluronic® triblock copolymer P123 core-shell micelles (RuMs). Complex 1 was highly active, with and without neutron irradiation, towards human ovarian cancer cells (A2780; IC50 0.14 μM and 0.17 μM, respectively) and cisplatin-resistant human ovarian cancer cells (A2780cisR; IC50 0.05 and 0.13 μM, respectively). Complex 1 was particularly sensitive to neutron irradiation in A2780cisR cells (2.6 × more potent after irradiation compared to non-irradiation). Although less potent, the encapsulated complex 1 as RuMs nanoparticles resulted in higher cellular accumulation (2.5×), and was sensitive to neutron irradiation in A2780 cells (1.4× more potent upon irradiation compared to non-irradiation).

Original languageEnglish
Pages (from-to)17-25
Number of pages9
JournalJournal of Organometallic Chemistry
Volume796
Early online date18 May 2015
DOIs
Publication statusPublished - 1 Nov 2015

Keywords

  • Arene ruthenium
  • Boron neutron capture therapy
  • Carborane
  • Micelles
  • Pluronic

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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