Are ultrasound salivary parenchymal lesions more severe in primary Sjögren patients with a longer disease duration? A cross-sectional study

Alice Tison; Sandrine Jousse-Joulin; Maëlys Consigny; Philipp Moog; Benedikt Hofauer; Eric Hachulla; Christophe Lamotte; Jacques Morel; Gaël Mouterde; Vera Milic; Hendrika Bootsma; Alja Stel; Benjamin A Fisher; Marc Maybury; Alan Baer; Dana DiRenzo; Hae-Rim Kim; Hong-Ki Min; Shin-Seok Lee; Sung-Eun Choi; Guillermo Carvajal Alegria; Sylvie Boisramé; Dewi Guellec; Divi Cornec; Baptiste Quéré; Malin Jonsson; Daniel Hammenfors; Alain Saraux; Valérie Devauchelle-Pensec

doi:10.1093/rheumatology/keae690

Are ultrasound salivary parenchymal lesions more severe in primary Sjögren patients with a longer disease duration? A cross-sectional study

Alice Tison^*, Sandrine Jousse-Joulin, Maëlys Consigny, Philipp Moog, Benedikt Hofauer, Eric Hachulla, Christophe Lamotte, Jacques Morel, Gaël Mouterde, Vera Milic, Hendrika Bootsma, Alja Stel, Benjamin A Fisher, Marc Maybury, Alan Baer, Dana DiRenzo, Hae-Rim Kim, Hong-Ki Min, Shin-Seok Lee, Sung-Eun ChoiGuillermo Carvajal Alegria, Sylvie Boisramé, Dewi Guellec, Divi Cornec, Baptiste Quéré, Malin Jonsson, Daniel Hammenfors, Alain Saraux, Valérie Devauchelle-Pensec

^*Corresponding author for this work

Inflammation and Ageing

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVES: Salivary gland ultrasound (SGUS) has an interest in primary Sjögren's disease (pSD) for diagnosis, but the evolution of parenchymal lesions over time is unknown. The objective of this study was to assess the severity of ultrasound abnormalities in relation to pSD duration from the time of buccal dryness onset.

METHODS: In this cross-sectional international multicentre study, patients with pSD according to the 2002 or 2016 ACR/EULAR classification criteria were included. Parenchymal abnormalities were classified according to the semiquantitative score as defined by OMERACT. Patients were separated into 4 groups (Group A: < 5 years, Group B: 5-9 years, Group C: 10-20 years, and Group D: > 20 years from the onset of buccal dryness). The association between disease duration groups and SGUS lesions was quantified in terms of odds ratios and 95% confidence intervals.

RESULTS: A total of 247 patients were consecutively included between May 2019 and February 2022. Eighty-nine percent of patients had a focus score ≥1/4 mm2, and 85% had positive anti-Ro/SSA. pSD duration was associated with a pathological OMERACT score (score 2 or 3): OR for 5-year duration: 1.23 [95% CI 1.04; 1.47], p= 0.0383). Considering each US item, the only statistical association with pSD duration was found regarding the presence of hyperechoic bands (25% or more): OR for five-year duration 1.18 [95% CI 1.03; 1.36], p= 0.038), independent of an older age.

CONCLUSION: pSD duration was associated with the presence of hyperechoic bands, but not with hypoechoic areas, suggesting a progressive fibro-adipose evolution.

Original language	English
Article number	keae690
Journal	Rheumatology
Early online date	19 Dec 2024
DOIs	https://doi.org/10.1093/rheumatology/keae690
Publication status	E-pub ahead of print - 19 Dec 2024

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Tison, A., Jousse-Joulin, S., Consigny, M., Moog, P., Hofauer, B., Hachulla, E., Lamotte, C., Morel, J., Mouterde, G., Milic, V., Bootsma, H., Stel, A., Fisher, B. A., Maybury, M., Baer, A., DiRenzo, D., Kim, H.-R., Min, H.-K., Lee, S.-S., ... Devauchelle-Pensec, V. (2024). Are ultrasound salivary parenchymal lesions more severe in primary Sjögren patients with a longer disease duration? A cross-sectional study. Rheumatology, Article keae690. Advance online publication. https://doi.org/10.1093/rheumatology/keae690

@article{aacbb6a3a46b47888a26056432cd7788,

title = "Are ultrasound salivary parenchymal lesions more severe in primary Sj{\"o}gren patients with a longer disease duration? A cross-sectional study",

abstract = "OBJECTIVES: Salivary gland ultrasound (SGUS) has an interest in primary Sj{\"o}gren's disease (pSD) for diagnosis, but the evolution of parenchymal lesions over time is unknown. The objective of this study was to assess the severity of ultrasound abnormalities in relation to pSD duration from the time of buccal dryness onset.METHODS: In this cross-sectional international multicentre study, patients with pSD according to the 2002 or 2016 ACR/EULAR classification criteria were included. Parenchymal abnormalities were classified according to the semiquantitative score as defined by OMERACT. Patients were separated into 4 groups (Group A: < 5 years, Group B: 5-9 years, Group C: 10-20 years, and Group D: > 20 years from the onset of buccal dryness). The association between disease duration groups and SGUS lesions was quantified in terms of odds ratios and 95\% confidence intervals.RESULTS: A total of 247 patients were consecutively included between May 2019 and February 2022. Eighty-nine percent of patients had a focus score ≥1/4 mm2, and 85\% had positive anti-Ro/SSA. pSD duration was associated with a pathological OMERACT score (score 2 or 3): OR for 5-year duration: 1.23 [95\% CI 1.04; 1.47], p= 0.0383). Considering each US item, the only statistical association with pSD duration was found regarding the presence of hyperechoic bands (25\% or more): OR for five-year duration 1.18 [95\% CI 1.03; 1.36], p= 0.038), independent of an older age.CONCLUSION: pSD duration was associated with the presence of hyperechoic bands, but not with hypoechoic areas, suggesting a progressive fibro-adipose evolution.",

author = "Alice Tison and Sandrine Jousse-Joulin and Ma{\"e}lys Consigny and Philipp Moog and Benedikt Hofauer and Eric Hachulla and Christophe Lamotte and Jacques Morel and Ga{\"e}l Mouterde and Vera Milic and Hendrika Bootsma and Alja Stel and Fisher, \{Benjamin A\} and Marc Maybury and Alan Baer and Dana DiRenzo and Hae-Rim Kim and Hong-Ki Min and Shin-Seok Lee and Sung-Eun Choi and Alegria, \{Guillermo Carvajal\} and Sylvie Boisram{\'e} and Dewi Guellec and Divi Cornec and Baptiste Qu{\'e}r{\'e} and Malin Jonsson and Daniel Hammenfors and Alain Saraux and Val{\'e}rie Devauchelle-Pensec",

note = "{\textcopyright} The Author(s) 2024. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: [email protected].",

year = "2024",

month = dec,

day = "19",

doi = "10.1093/rheumatology/keae690",

language = "English",

journal = "Rheumatology",

issn = "1462-0324",

publisher = "Oxford University Press",

}

Tison, A, Jousse-Joulin, S, Consigny, M, Moog, P, Hofauer, B, Hachulla, E, Lamotte, C, Morel, J, Mouterde, G, Milic, V, Bootsma, H, Stel, A, Fisher, BA, Maybury, M, Baer, A, DiRenzo, D, Kim, H-R, Min, H-K, Lee, S-S, Choi, S-E, Alegria, GC, Boisramé, S, Guellec, D, Cornec, D, Quéré, B, Jonsson, M, Hammenfors, D, Saraux, A & Devauchelle-Pensec, V 2024, 'Are ultrasound salivary parenchymal lesions more severe in primary Sjögren patients with a longer disease duration? A cross-sectional study', Rheumatology. https://doi.org/10.1093/rheumatology/keae690

TY - JOUR

T1 - Are ultrasound salivary parenchymal lesions more severe in primary Sjögren patients with a longer disease duration? A cross-sectional study

AU - Tison, Alice

AU - Jousse-Joulin, Sandrine

AU - Consigny, Maëlys

AU - Moog, Philipp

AU - Hofauer, Benedikt

AU - Hachulla, Eric

AU - Lamotte, Christophe

AU - Morel, Jacques

AU - Mouterde, Gaël

AU - Milic, Vera

AU - Bootsma, Hendrika

AU - Stel, Alja

AU - Fisher, Benjamin A

AU - Maybury, Marc

AU - Baer, Alan

AU - DiRenzo, Dana

AU - Kim, Hae-Rim

AU - Min, Hong-Ki

AU - Lee, Shin-Seok

AU - Choi, Sung-Eun

AU - Alegria, Guillermo Carvajal

AU - Boisramé, Sylvie

AU - Guellec, Dewi

AU - Cornec, Divi

AU - Quéré, Baptiste

AU - Jonsson, Malin

AU - Hammenfors, Daniel

AU - Saraux, Alain

AU - Devauchelle-Pensec, Valérie

PY - 2024/12/19

Y1 - 2024/12/19

N2 - OBJECTIVES: Salivary gland ultrasound (SGUS) has an interest in primary Sjögren's disease (pSD) for diagnosis, but the evolution of parenchymal lesions over time is unknown. The objective of this study was to assess the severity of ultrasound abnormalities in relation to pSD duration from the time of buccal dryness onset.METHODS: In this cross-sectional international multicentre study, patients with pSD according to the 2002 or 2016 ACR/EULAR classification criteria were included. Parenchymal abnormalities were classified according to the semiquantitative score as defined by OMERACT. Patients were separated into 4 groups (Group A: < 5 years, Group B: 5-9 years, Group C: 10-20 years, and Group D: > 20 years from the onset of buccal dryness). The association between disease duration groups and SGUS lesions was quantified in terms of odds ratios and 95% confidence intervals.RESULTS: A total of 247 patients were consecutively included between May 2019 and February 2022. Eighty-nine percent of patients had a focus score ≥1/4 mm2, and 85% had positive anti-Ro/SSA. pSD duration was associated with a pathological OMERACT score (score 2 or 3): OR for 5-year duration: 1.23 [95% CI 1.04; 1.47], p= 0.0383). Considering each US item, the only statistical association with pSD duration was found regarding the presence of hyperechoic bands (25% or more): OR for five-year duration 1.18 [95% CI 1.03; 1.36], p= 0.038), independent of an older age.CONCLUSION: pSD duration was associated with the presence of hyperechoic bands, but not with hypoechoic areas, suggesting a progressive fibro-adipose evolution.

AB - OBJECTIVES: Salivary gland ultrasound (SGUS) has an interest in primary Sjögren's disease (pSD) for diagnosis, but the evolution of parenchymal lesions over time is unknown. The objective of this study was to assess the severity of ultrasound abnormalities in relation to pSD duration from the time of buccal dryness onset.METHODS: In this cross-sectional international multicentre study, patients with pSD according to the 2002 or 2016 ACR/EULAR classification criteria were included. Parenchymal abnormalities were classified according to the semiquantitative score as defined by OMERACT. Patients were separated into 4 groups (Group A: < 5 years, Group B: 5-9 years, Group C: 10-20 years, and Group D: > 20 years from the onset of buccal dryness). The association between disease duration groups and SGUS lesions was quantified in terms of odds ratios and 95% confidence intervals.RESULTS: A total of 247 patients were consecutively included between May 2019 and February 2022. Eighty-nine percent of patients had a focus score ≥1/4 mm2, and 85% had positive anti-Ro/SSA. pSD duration was associated with a pathological OMERACT score (score 2 or 3): OR for 5-year duration: 1.23 [95% CI 1.04; 1.47], p= 0.0383). Considering each US item, the only statistical association with pSD duration was found regarding the presence of hyperechoic bands (25% or more): OR for five-year duration 1.18 [95% CI 1.03; 1.36], p= 0.038), independent of an older age.CONCLUSION: pSD duration was associated with the presence of hyperechoic bands, but not with hypoechoic areas, suggesting a progressive fibro-adipose evolution.

U2 - 10.1093/rheumatology/keae690

DO - 10.1093/rheumatology/keae690

M3 - Article

C2 - 39700419

SN - 1462-0324

JO - Rheumatology

JF - Rheumatology

M1 - keae690

ER -

Are ultrasound salivary parenchymal lesions more severe in primary Sjögren patients with a longer disease duration? A cross-sectional study

Abstract

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