Arabinofuranose disaccharide analogs as inhibitors of Mycobacterium tuberculosis

AK Pathak, V Pathak, M Kulshrestha, D Kinnaird, WJ Suling, Sudagar Gurcha, Gurdyal Besra

Research output: Contribution to journalArticle

20 Citations (Scopus)


Several octyl 5-O-(alpha-D-arabinofuranosyl)-alpha-D-arabinofuranoside disaccharide analogs substituted at the 5-position of the non-reducing end sugar were synthesized and tested in vitro against Mycobacterium tuberculosis (M.tb.), Mycobacterium avium complex (MAC) as well as in a cell free assay system for arabinosyltransferase acceptor/inhibitor activity. A few compounds showed interesting inhibitory activity in the cell free assay as well as against the whole microorganism in vitro. (C) 2003 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)10239-10248
Number of pages10
Issue number51
Publication statusPublished - 15 Dec 2003


  • inhibitors
  • arabinofuranose
  • glycosyltransferase
  • Mycobacterium tuberculosis


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