Arabinofuranose disaccharide analogs as inhibitors of Mycobacterium tuberculosis

AK Pathak; V Pathak; M Kulshrestha; D Kinnaird; WJ Suling; Sudagar Gurcha; Gurdyal Besra

doi:10.1016/j.tet.2003.10.054

Arabinofuranose disaccharide analogs as inhibitors of Mycobacterium tuberculosis

AK Pathak, V Pathak, M Kulshrestha, D Kinnaird, WJ Suling, Sudagar Gurcha, Gurdyal Besra

Biosciences

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Abstract

Several octyl 5-O-(alpha-D-arabinofuranosyl)-alpha-D-arabinofuranoside disaccharide analogs substituted at the 5-position of the non-reducing end sugar were synthesized and tested in vitro against Mycobacterium tuberculosis (M.tb.), Mycobacterium avium complex (MAC) as well as in a cell free assay system for arabinosyltransferase acceptor/inhibitor activity. A few compounds showed interesting inhibitory activity in the cell free assay as well as against the whole microorganism in vitro. (C) 2003 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	10239-10248
Number of pages	10
Journal	Tetrahedron
Volume	59
Issue number	51
DOIs	https://doi.org/10.1016/j.tet.2003.10.054
Publication status	Published - 15 Dec 2003

Keywords

inhibitors
arabinofuranose
glycosyltransferase
Mycobacterium tuberculosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tet.2003.10.054

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title = "Arabinofuranose disaccharide analogs as inhibitors of Mycobacterium tuberculosis",

abstract = "Several octyl 5-O-(alpha-D-arabinofuranosyl)-alpha-D-arabinofuranoside disaccharide analogs substituted at the 5-position of the non-reducing end sugar were synthesized and tested in vitro against Mycobacterium tuberculosis (M.tb.), Mycobacterium avium complex (MAC) as well as in a cell free assay system for arabinosyltransferase acceptor/inhibitor activity. A few compounds showed interesting inhibitory activity in the cell free assay as well as against the whole microorganism in vitro. (C) 2003 Elsevier Ltd. All rights reserved.",

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T1 - Arabinofuranose disaccharide analogs as inhibitors of Mycobacterium tuberculosis

AU - Pathak, AK

AU - Pathak, V

AU - Kulshrestha, M

AU - Kinnaird, D

AU - Suling, WJ

AU - Gurcha, Sudagar

AU - Besra, Gurdyal

PY - 2003/12/15

Y1 - 2003/12/15

N2 - Several octyl 5-O-(alpha-D-arabinofuranosyl)-alpha-D-arabinofuranoside disaccharide analogs substituted at the 5-position of the non-reducing end sugar were synthesized and tested in vitro against Mycobacterium tuberculosis (M.tb.), Mycobacterium avium complex (MAC) as well as in a cell free assay system for arabinosyltransferase acceptor/inhibitor activity. A few compounds showed interesting inhibitory activity in the cell free assay as well as against the whole microorganism in vitro. (C) 2003 Elsevier Ltd. All rights reserved.

AB - Several octyl 5-O-(alpha-D-arabinofuranosyl)-alpha-D-arabinofuranoside disaccharide analogs substituted at the 5-position of the non-reducing end sugar were synthesized and tested in vitro against Mycobacterium tuberculosis (M.tb.), Mycobacterium avium complex (MAC) as well as in a cell free assay system for arabinosyltransferase acceptor/inhibitor activity. A few compounds showed interesting inhibitory activity in the cell free assay as well as against the whole microorganism in vitro. (C) 2003 Elsevier Ltd. All rights reserved.

KW - inhibitors

KW - arabinofuranose

KW - glycosyltransferase

KW - Mycobacterium tuberculosis

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DO - 10.1016/j.tet.2003.10.054

M3 - Article

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SP - 10239

EP - 10248

JO - Tetrahedron

JF - Tetrahedron

IS - 51

ER -

Arabinofuranose disaccharide analogs as inhibitors of Mycobacterium tuberculosis

Abstract

Keywords

UN SDGs

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