Aqueous humour analysis in Fuchs' heterochromic cyclitis

P I Murray; R Hoekzema; M A van Haren; L Luyendijk; A Kijlstra

Aqueous humour analysis in Fuchs' heterochromic cyclitis

P I Murray, R Hoekzema, M A van Haren, L Luyendijk, A Kijlstra

Immunology and Immunotherapy

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Abstract

Aqueous humor from 23 patients with Fuchs' heterochromic cyclitis (FHC) was analysed by a number of immunological methods. Intraocular IgG synthesis was found in 65% of patients and oligoclonal IgG bands, mainly of the IgG1 subclass, identified in 57%. There was a relative increase in IgG1 (P less than 0.01) as compared to patients with senile cataract. Local production of the cytokine Interleukin-6 was demonstrated in 63% of patients (P less than 0.01). Analysis of aqueous by HPLC and SDS-PAGE failed to reveal any abnormalities specific for FHC. These findings add further evidence to the theory of immune dysregulation in this condition.

Original language	English
Pages (from-to)	53-7
Number of pages	5
Journal	Current eye research
Volume	9 Suppl
Publication status	Published - 1990

Cite this

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title = "Aqueous humour analysis in Fuchs' heterochromic cyclitis",

abstract = "Aqueous humor from 23 patients with Fuchs' heterochromic cyclitis (FHC) was analysed by a number of immunological methods. Intraocular IgG synthesis was found in 65\% of patients and oligoclonal IgG bands, mainly of the IgG1 subclass, identified in 57\%. There was a relative increase in IgG1 (P less than 0.01) as compared to patients with senile cataract. Local production of the cytokine Interleukin-6 was demonstrated in 63\% of patients (P less than 0.01). Analysis of aqueous by HPLC and SDS-PAGE failed to reveal any abnormalities specific for FHC. These findings add further evidence to the theory of immune dysregulation in this condition.",

author = "Murray, \{P I\} and R Hoekzema and \{van Haren\}, \{M A\} and L Luyendijk and A Kijlstra",

year = "1990",

language = "English",

volume = "9 Suppl",

pages = "53--7",

journal = "Current eye research",

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publisher = "Taylor \& Francis",

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T1 - Aqueous humour analysis in Fuchs' heterochromic cyclitis

AU - Murray, P I

AU - Hoekzema, R

AU - van Haren, M A

AU - Luyendijk, L

AU - Kijlstra, A

PY - 1990

Y1 - 1990

N2 - Aqueous humor from 23 patients with Fuchs' heterochromic cyclitis (FHC) was analysed by a number of immunological methods. Intraocular IgG synthesis was found in 65% of patients and oligoclonal IgG bands, mainly of the IgG1 subclass, identified in 57%. There was a relative increase in IgG1 (P less than 0.01) as compared to patients with senile cataract. Local production of the cytokine Interleukin-6 was demonstrated in 63% of patients (P less than 0.01). Analysis of aqueous by HPLC and SDS-PAGE failed to reveal any abnormalities specific for FHC. These findings add further evidence to the theory of immune dysregulation in this condition.

AB - Aqueous humor from 23 patients with Fuchs' heterochromic cyclitis (FHC) was analysed by a number of immunological methods. Intraocular IgG synthesis was found in 65% of patients and oligoclonal IgG bands, mainly of the IgG1 subclass, identified in 57%. There was a relative increase in IgG1 (P less than 0.01) as compared to patients with senile cataract. Local production of the cytokine Interleukin-6 was demonstrated in 63% of patients (P less than 0.01). Analysis of aqueous by HPLC and SDS-PAGE failed to reveal any abnormalities specific for FHC. These findings add further evidence to the theory of immune dysregulation in this condition.

M3 - Article

C2 - 2384014

SN - 0271-3683

VL - 9 Suppl

SP - 53

EP - 57

JO - Current eye research

JF - Current eye research

ER -

Aqueous humour analysis in Fuchs' heterochromic cyclitis

Abstract

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