Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase

Alessio De Simone; Gian Filippo Ruda; Clara Albani; Glauco Tarozzo; Tiziano Bandiera; Daniele Piomelli; Andrea Cavalli; Giovanni Bottegoni

doi:10.1039/c4cc00967c

Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase

Alessio De Simone
, Gian Filippo Ruda
, Clara Albani
, Glauco Tarozzo
, Tiziano Bandiera
, Daniele Piomelli
, Andrea Cavalli
, Giovanni Bottegoni^*

^*Corresponding author for this work

Pharmacy

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Combining computer-assisted drug design and synthetic efforts, we generated compounds with potent and balanced activities toward both D3 dopamine receptor and fatty acid amide hydrolase (FAAH) enzyme. By concurrently modulating these targets, our compounds hold great potential toward exerting a disease-modifying effect on nicotine addiction and other forms of compulsive behavior.

Original language	English
Pages (from-to)	4904-4907
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	38
Early online date	25 Mar 2014
DOIs	https://doi.org/10.1039/c4cc00967c
Publication status	Published - 18 May 2014

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/c4cc00967cLicence: None: All rights reserved

Cite this

De Simone, A., Ruda, G. F., Albani, C., Tarozzo, G., Bandiera, T., Piomelli, D., Cavalli, A., & Bottegoni, G. (2014). Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase. Chemical Communications, 50(38), 4904-4907. https://doi.org/10.1039/c4cc00967c

@article{8552b514cb08448c8f2593722c974be9,

title = "Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase",

abstract = "Combining computer-assisted drug design and synthetic efforts, we generated compounds with potent and balanced activities toward both D3 dopamine receptor and fatty acid amide hydrolase (FAAH) enzyme. By concurrently modulating these targets, our compounds hold great potential toward exerting a disease-modifying effect on nicotine addiction and other forms of compulsive behavior.",

author = "\{De Simone\}, Alessio and Ruda, \{Gian Filippo\} and Clara Albani and Glauco Tarozzo and Tiziano Bandiera and Daniele Piomelli and Andrea Cavalli and Giovanni Bottegoni",

year = "2014",

month = may,

day = "18",

doi = "10.1039/c4cc00967c",

language = "English",

volume = "50",

pages = "4904--4907",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "38",

}

De Simone, A, Ruda, GF, Albani, C, Tarozzo, G, Bandiera, T, Piomelli, D, Cavalli, A & Bottegoni, G 2014, 'Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase', Chemical Communications, vol. 50, no. 38, pp. 4904-4907. https://doi.org/10.1039/c4cc00967c

Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase. / De Simone, Alessio; Ruda, Gian Filippo; Albani, Clara et al.
In: Chemical Communications, Vol. 50, No. 38, 18.05.2014, p. 4904-4907.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Applying a multitarget rational drug design strategy

T2 - the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase

AU - De Simone, Alessio

AU - Ruda, Gian Filippo

AU - Albani, Clara

AU - Tarozzo, Glauco

AU - Bandiera, Tiziano

AU - Piomelli, Daniele

AU - Cavalli, Andrea

AU - Bottegoni, Giovanni

PY - 2014/5/18

Y1 - 2014/5/18

N2 - Combining computer-assisted drug design and synthetic efforts, we generated compounds with potent and balanced activities toward both D3 dopamine receptor and fatty acid amide hydrolase (FAAH) enzyme. By concurrently modulating these targets, our compounds hold great potential toward exerting a disease-modifying effect on nicotine addiction and other forms of compulsive behavior.

AB - Combining computer-assisted drug design and synthetic efforts, we generated compounds with potent and balanced activities toward both D3 dopamine receptor and fatty acid amide hydrolase (FAAH) enzyme. By concurrently modulating these targets, our compounds hold great potential toward exerting a disease-modifying effect on nicotine addiction and other forms of compulsive behavior.

UR - https://www.scopus.com/pages/publications/84898862444

U2 - 10.1039/c4cc00967c

DO - 10.1039/c4cc00967c

M3 - Article

C2 - 24691497

AN - SCOPUS:84898862444

SN - 1359-7345

VL - 50

SP - 4904

EP - 4907

JO - Chemical Communications

JF - Chemical Communications

IS - 38

ER -

Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase

Abstract

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this