Applications of Stem Cell-Derived Extracellular Vesicles in Nerve Regeneration

Burcak Yavuz; Esra Cansever Mutlu; Zubair Ahmed; Besim Ben-Nissan; Artemis Stamboulis

doi:10.3390/ijms25115863

Applications of Stem Cell-Derived Extracellular Vesicles in Nerve Regeneration

Burcak Yavuz
, Esra Cansever Mutlu
, Zubair Ahmed^*
, Besim Ben-Nissan
, Artemis Stamboulis^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

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Abstract

Extracellular vesicles (EVs), including exosomes, microvesicles, and other lipid vesicles derived from cells, play a pivotal role in intercellular communication by transferring information between cells. EVs secreted by progenitor and stem cells have been associated with the therapeutic effects observed in cell-based therapies, and they also contribute to tissue regeneration following injury, such as in orthopaedic surgery cases. This review explores the involvement of EVs in nerve regeneration, their potential as drug carriers, and their significance in stem cell research and cell-free therapies. It underscores the importance of bioengineers comprehending and manipulating EV activity to optimize the efficacy of tissue engineering and regenerative therapies.

Original language	English
Article number	5863
Number of pages	26
Journal	International Journal of Molecular Sciences
Volume	25
Issue number	11
DOIs	https://doi.org/10.3390/ijms25115863
Publication status	Published - 28 May 2024

Keywords

exosome
non-coding RNAs
blood-brain barrier
nerve regeneration
traumatic brain injury

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title = "Applications of Stem Cell-Derived Extracellular Vesicles in Nerve Regeneration",

abstract = "Extracellular vesicles (EVs), including exosomes, microvesicles, and other lipid vesicles derived from cells, play a pivotal role in intercellular communication by transferring information between cells. EVs secreted by progenitor and stem cells have been associated with the therapeutic effects observed in cell-based therapies, and they also contribute to tissue regeneration following injury, such as in orthopaedic surgery cases. This review explores the involvement of EVs in nerve regeneration, their potential as drug carriers, and their significance in stem cell research and cell-free therapies. It underscores the importance of bioengineers comprehending and manipulating EV activity to optimize the efficacy of tissue engineering and regenerative therapies.",

keywords = "exosome, non-coding RNAs, blood-brain barrier, nerve regeneration, traumatic brain injury",

author = "Burcak Yavuz and Mutlu, \{Esra Cansever\} and Zubair Ahmed and Besim Ben-Nissan and Artemis Stamboulis",

year = "2024",

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journal = "International Journal of Molecular Sciences",

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T1 - Applications of Stem Cell-Derived Extracellular Vesicles in Nerve Regeneration

AU - Yavuz, Burcak

AU - Mutlu, Esra Cansever

AU - Ahmed, Zubair

AU - Ben-Nissan, Besim

AU - Stamboulis, Artemis

PY - 2024/5/28

Y1 - 2024/5/28

N2 - Extracellular vesicles (EVs), including exosomes, microvesicles, and other lipid vesicles derived from cells, play a pivotal role in intercellular communication by transferring information between cells. EVs secreted by progenitor and stem cells have been associated with the therapeutic effects observed in cell-based therapies, and they also contribute to tissue regeneration following injury, such as in orthopaedic surgery cases. This review explores the involvement of EVs in nerve regeneration, their potential as drug carriers, and their significance in stem cell research and cell-free therapies. It underscores the importance of bioengineers comprehending and manipulating EV activity to optimize the efficacy of tissue engineering and regenerative therapies.

AB - Extracellular vesicles (EVs), including exosomes, microvesicles, and other lipid vesicles derived from cells, play a pivotal role in intercellular communication by transferring information between cells. EVs secreted by progenitor and stem cells have been associated with the therapeutic effects observed in cell-based therapies, and they also contribute to tissue regeneration following injury, such as in orthopaedic surgery cases. This review explores the involvement of EVs in nerve regeneration, their potential as drug carriers, and their significance in stem cell research and cell-free therapies. It underscores the importance of bioengineers comprehending and manipulating EV activity to optimize the efficacy of tissue engineering and regenerative therapies.

KW - exosome

KW - non-coding RNAs

KW - blood-brain barrier

KW - nerve regeneration

KW - traumatic brain injury

U2 - 10.3390/ijms25115863

DO - 10.3390/ijms25115863

M3 - Review article

SN - 1661-6596

VL - 25

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 11

M1 - 5863

ER -

Applications of Stem Cell-Derived Extracellular Vesicles in Nerve Regeneration

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Keywords

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