Apolipoprotein E-epsilon 4 and recurrent genital herpes in individuals co-infected with herpes simplex virus type 2 and HIV.

AN Jayasuriya; RF Itzhaki; MA Wozniak; R Patel; EJ Smit; R Noone; G Gilleran; Stephen Taylor; DJ White

doi:10.1136/sti.2008.032367

Apolipoprotein E-epsilon 4 and recurrent genital herpes in individuals co-infected with herpes simplex virus type 2 and HIV.

AN Jayasuriya, RF Itzhaki, MA Wozniak, R Patel, EJ Smit, R Noone, G Gilleran, Stephen Taylor, DJ White

Immunology and Immunotherapy

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Abstract

Apolipoprotein E (APOE) alleles have been associated with the severity of, or susceptibility to, infection by various microbes. We investigated the potential association between the APOE-epsilon 4 allele and the rate of recurrence of genital herpes in patients who were HIV positive and herpes simplex virus type 2 (HSV-2) seropositive. The APOE-epsilon 4 allele was significantly associated with recurrent genital ulceration independent of ethnicity, antiretroviral therapy and CD4 count (OR 8.3; 95% CI 2.4 to 28.5). To our knowledge, this is the first published study to demonstrate this association and suggests that APOE-epsilon 4 may represent a future prognostic marker for symptomatic recurrence of genital herpes in individuals with HIV.

Original language	English
Pages (from-to)	516-7
Number of pages	2
Journal	Sexually Transmitted Infections
Volume	84
Issue number	7
DOIs	https://doi.org/10.1136/sti.2008.032367
Publication status	Published - 1 Dec 2008

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title = "Apolipoprotein E-epsilon 4 and recurrent genital herpes in individuals co-infected with herpes simplex virus type 2 and HIV.",

abstract = "Apolipoprotein E (APOE) alleles have been associated with the severity of, or susceptibility to, infection by various microbes. We investigated the potential association between the APOE-epsilon 4 allele and the rate of recurrence of genital herpes in patients who were HIV positive and herpes simplex virus type 2 (HSV-2) seropositive. The APOE-epsilon 4 allele was significantly associated with recurrent genital ulceration independent of ethnicity, antiretroviral therapy and CD4 count (OR 8.3; 95% CI 2.4 to 28.5). To our knowledge, this is the first published study to demonstrate this association and suggests that APOE-epsilon 4 may represent a future prognostic marker for symptomatic recurrence of genital herpes in individuals with HIV.",

author = "AN Jayasuriya and RF Itzhaki and MA Wozniak and R Patel and EJ Smit and R Noone and G Gilleran and Stephen Taylor and DJ White",

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T1 - Apolipoprotein E-epsilon 4 and recurrent genital herpes in individuals co-infected with herpes simplex virus type 2 and HIV.

AU - Jayasuriya, AN

AU - Itzhaki, RF

AU - Wozniak, MA

AU - Patel, R

AU - Smit, EJ

AU - Noone, R

AU - Gilleran, G

AU - Taylor, Stephen

AU - White, DJ

PY - 2008/12/1

Y1 - 2008/12/1

N2 - Apolipoprotein E (APOE) alleles have been associated with the severity of, or susceptibility to, infection by various microbes. We investigated the potential association between the APOE-epsilon 4 allele and the rate of recurrence of genital herpes in patients who were HIV positive and herpes simplex virus type 2 (HSV-2) seropositive. The APOE-epsilon 4 allele was significantly associated with recurrent genital ulceration independent of ethnicity, antiretroviral therapy and CD4 count (OR 8.3; 95% CI 2.4 to 28.5). To our knowledge, this is the first published study to demonstrate this association and suggests that APOE-epsilon 4 may represent a future prognostic marker for symptomatic recurrence of genital herpes in individuals with HIV.

AB - Apolipoprotein E (APOE) alleles have been associated with the severity of, or susceptibility to, infection by various microbes. We investigated the potential association between the APOE-epsilon 4 allele and the rate of recurrence of genital herpes in patients who were HIV positive and herpes simplex virus type 2 (HSV-2) seropositive. The APOE-epsilon 4 allele was significantly associated with recurrent genital ulceration independent of ethnicity, antiretroviral therapy and CD4 count (OR 8.3; 95% CI 2.4 to 28.5). To our knowledge, this is the first published study to demonstrate this association and suggests that APOE-epsilon 4 may represent a future prognostic marker for symptomatic recurrence of genital herpes in individuals with HIV.

U2 - 10.1136/sti.2008.032367

DO - 10.1136/sti.2008.032367

M3 - Article

C2 - 18708484

SN - 1472-3263

VL - 84

SP - 516

EP - 517

JO - Sexually Transmitted Infections

JF - Sexually Transmitted Infections

IS - 7

ER -

Apolipoprotein E-epsilon 4 and recurrent genital herpes in individuals co-infected with herpes simplex virus type 2 and HIV.

Abstract

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