Aortic Arch Calcification and Vascular Disease: The Guangzhou Biobank Cohort Study

L Xu, CQ Jiang, TH Lam, Graham Thomas, WS Zhang, Kar Cheng

    Research output: Contribution to journalArticle

    8 Citations (Scopus)


    Objective: To examine the association between aortic arch calcification (AAC) and vascular disease in an older Chinese sample. Methods: For this study, 30,203 Chinese aged 50-85 years were recruited with baseline information on socioeconomic position, lifestyle and vascular risk factors. The presence and severity of AAC were diagnosed independently from chest X-ray by two radiologists. Results: The age-adjusted prevalence of AAC was significantly higher in women than men [34.6% (95% Cl 33.9-35.3) vs. 27.9% (95% Cl 26.8-28.8), p <0.001]. Severity of AAC was significantly associated with physician-diagnosed ischemic heart disease (adjusted OR = 1.55, 95% Cl 1.35-1.79) and combined vascular disease (OR = 1.48,95% Cl 1.30-1.69) after adjusting for multiple potential confounders. Increasing severity of AAC was associated with increased risk for ischemic heart disease and vascular disease (p for trend = 0.02 to
    Original languageEnglish
    Pages (from-to)260-264
    Number of pages5
    Issue number4
    Publication statusPublished - 1 Jan 2010


    • Vascular disease
    • Aortic arch calcification
    • Stroke
    • Ischemic heart disease


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