Aortic Arch Calcification and Vascular Disease: The Guangzhou Biobank Cohort Study

L Xu; CQ Jiang; TH Lam; Graham Thomas; WS Zhang; Kar Cheng

doi:10.1159/000323285

Aortic Arch Calcification and Vascular Disease: The Guangzhou Biobank Cohort Study

L Xu, CQ Jiang, TH Lam, Graham Thomas, WS Zhang, Kar Cheng

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Abstract

Objective: To examine the association between aortic arch calcification (AAC) and vascular disease in an older Chinese sample. Methods: For this study, 30,203 Chinese aged 50-85 years were recruited with baseline information on socioeconomic position, lifestyle and vascular risk factors. The presence and severity of AAC were diagnosed independently from chest X-ray by two radiologists. Results: The age-adjusted prevalence of AAC was significantly higher in women than men [34.6% (95% Cl 33.9-35.3) vs. 27.9% (95% Cl 26.8-28.8), p <0.001]. Severity of AAC was significantly associated with physician-diagnosed ischemic heart disease (adjusted OR = 1.55, 95% Cl 1.35-1.79) and combined vascular disease (OR = 1.48,95% Cl 1.30-1.69) after adjusting for multiple potential confounders. Increasing severity of AAC was associated with increased risk for ischemic heart disease and vascular disease (p for trend = 0.02 to

Original language	English
Pages (from-to)	260-264
Number of pages	5
Journal	Cardiology
Volume	117
Issue number	4
DOIs	https://doi.org/10.1159/000323285
Publication status	Published - 1 Jan 2010

Keywords

Vascular disease
Aortic arch calcification
Stroke
Ischemic heart disease

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10.1159/000323285

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title = "Aortic Arch Calcification and Vascular Disease: The Guangzhou Biobank Cohort Study",

abstract = "Objective: To examine the association between aortic arch calcification (AAC) and vascular disease in an older Chinese sample. Methods: For this study, 30,203 Chinese aged 50-85 years were recruited with baseline information on socioeconomic position, lifestyle and vascular risk factors. The presence and severity of AAC were diagnosed independently from chest X-ray by two radiologists. Results: The age-adjusted prevalence of AAC was significantly higher in women than men [34.6% (95% Cl 33.9-35.3) vs. 27.9% (95% Cl 26.8-28.8), p <0.001]. Severity of AAC was significantly associated with physician-diagnosed ischemic heart disease (adjusted OR = 1.55, 95% Cl 1.35-1.79) and combined vascular disease (OR = 1.48,95% Cl 1.30-1.69) after adjusting for multiple potential confounders. Increasing severity of AAC was associated with increased risk for ischemic heart disease and vascular disease (p for trend = 0.02 to ",

keywords = "Vascular disease, Aortic arch calcification, Stroke, Ischemic heart disease",

author = "L Xu and CQ Jiang and TH Lam and Graham Thomas and WS Zhang and Kar Cheng",

year = "2010",

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doi = "10.1159/000323285",

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pages = "260--264",

journal = "Cardiology",

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T1 - Aortic Arch Calcification and Vascular Disease: The Guangzhou Biobank Cohort Study

AU - Xu, L

AU - Jiang, CQ

AU - Lam, TH

AU - Thomas, Graham

AU - Zhang, WS

AU - Cheng, Kar

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Objective: To examine the association between aortic arch calcification (AAC) and vascular disease in an older Chinese sample. Methods: For this study, 30,203 Chinese aged 50-85 years were recruited with baseline information on socioeconomic position, lifestyle and vascular risk factors. The presence and severity of AAC were diagnosed independently from chest X-ray by two radiologists. Results: The age-adjusted prevalence of AAC was significantly higher in women than men [34.6% (95% Cl 33.9-35.3) vs. 27.9% (95% Cl 26.8-28.8), p <0.001]. Severity of AAC was significantly associated with physician-diagnosed ischemic heart disease (adjusted OR = 1.55, 95% Cl 1.35-1.79) and combined vascular disease (OR = 1.48,95% Cl 1.30-1.69) after adjusting for multiple potential confounders. Increasing severity of AAC was associated with increased risk for ischemic heart disease and vascular disease (p for trend = 0.02 to

AB - Objective: To examine the association between aortic arch calcification (AAC) and vascular disease in an older Chinese sample. Methods: For this study, 30,203 Chinese aged 50-85 years were recruited with baseline information on socioeconomic position, lifestyle and vascular risk factors. The presence and severity of AAC were diagnosed independently from chest X-ray by two radiologists. Results: The age-adjusted prevalence of AAC was significantly higher in women than men [34.6% (95% Cl 33.9-35.3) vs. 27.9% (95% Cl 26.8-28.8), p <0.001]. Severity of AAC was significantly associated with physician-diagnosed ischemic heart disease (adjusted OR = 1.55, 95% Cl 1.35-1.79) and combined vascular disease (OR = 1.48,95% Cl 1.30-1.69) after adjusting for multiple potential confounders. Increasing severity of AAC was associated with increased risk for ischemic heart disease and vascular disease (p for trend = 0.02 to

KW - Vascular disease

KW - Aortic arch calcification

KW - Stroke

KW - Ischemic heart disease

U2 - 10.1159/000323285

DO - 10.1159/000323285

M3 - Article

C2 - 21252535

VL - 117

SP - 260

EP - 264

JO - Cardiology

JF - Cardiology

IS - 4

ER -

Aortic Arch Calcification and Vascular Disease: The Guangzhou Biobank Cohort Study

Abstract

Keywords

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