Antitumor activity and prolonged survival by carbon-nanotube-mediated therapeutic siRNA silencing in a human lung xenograft model

Keyphrases

• Xenograft Model 100%
• Antitumor Activity 100%
• Prolonged Survival 100%
• Human Lung 100%
• Small Interfering RNA (siRNA) 100%
• Carbon Nanotubes 100%
• SiRNA Silencing 100%
• RNA Therapeutics 100%
• NH 3 80%
• Liposomes 40%
• Clinical Application 20%
• Xenograft 20%
• Cytotoxicity 20%
• Cytotoxic Activity 20%
• DOTAP 20%
• Cell Death 20%
• Human Tumors 20%
• Tumor Growth 20%
• Improved Survival 20%
• Therapeutic Agents 20%
• Potential Gains 20%
• Cholesterol 20%
• Necrosis 20%
• Biologically Active 20%
• Intracellular Delivery 20%
• Tumor Volume 20%
• Tumor Mass 20%
• Biomedical Applications 20%
• Intratumoral Administration 20%
• Human Carcinoma Cells 20%
• Murine Cells 20%
• Human-specific 20%
• Human Lung Tumors 20%
• Cationic Liposomes 20%
• Local Delivery 20%
• Apoptotic Cascade 20%
• Functionalized Carbon Nanotubes 20%
• Novel Nanomaterials 20%
• Human Lung Carcinoma 20%
• Tumor-bearing Animals 20%
• Amino-functionalized Carbon Nanotubes 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Small Interfering RNA 100%
• Antitumor Activity 100%
• Carbon Nanotube 100%
• Liposome 50%
• Neoplasm 33%
• Cytotoxicity 33%
• Nanomaterial 16%
• Disease 16%
• 1,2 Dioleoyl 3 Trimethylammoniopropane 16%
• Tumor Growth 16%
• Lung Tumor 16%
• Carcinoma 16%
• Necrosis 16%
• Lung Carcinoma 16%
• Multi Walled Nanotube 16%