Antipneumolysin antibody titers in HIV-seropositive injection drug users before and after pneumococcal bacteremia

J H Sullivan, T J Mitchell, M C Steinhoff

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Lower baseline antipneumolysin antibody (alpha-PLY) levels have been found in populations with a higher incidence of pneumococcal infections. To determine whether predisease alpha-PLY titer is associated with invasive pneumococcal disease in HIV-seropositive injection drug users (IDU), we utilized a prospective cohort of IDU in Baltimore to compare alpha-PLY titers before bacteremia in 28 HIV- seropositive IDU cases with alpha-PLY titers in 56 matched (CD4 and seroconversion date) HIV-seropositive IDU control subjects and 28 matched (calendar time) HIV-seronegative IDU control subjects remaining free of pneumococcal disease. We also compared the postinfection fold-rise of alpha-PLY titers in cases relative to the change in alpha-PLY titers in control subjects during the same interval; alpha-PLY titers were measured using quantitative ELISA, and functional activity was assessed using antihemolysin assays. Predisease alpha-PLY titer did not differ between cases (66 units) and HIV-seropositive control subjects (70 units, p = 0.56) or HIV-seronegative control subjects (80 units, p = 0.10). There was a significant difference in fold-rise of alpha-PLY titers postdisease between cases (1.18) and HIV-seronegative control subjects (0.76), p = 0.03. Baseline alpha-PLY titers do not differ significantly between HIV-seropositive IDU who develop pneumococcal bacteremia from HIV-seropositive and HIV-seronegative IDU control subjects remaining free of severe pneumococcal disease.

Original languageEnglish
Pages (from-to)680-4
Number of pages5
JournalAmerican Journal of Respiratory and Critical Care Medicine
Issue number3 Pt 1
Publication statusPublished - Mar 2001


  • Adolescent
  • Adult
  • Antibodies
  • Bacteremia
  • Bacterial Proteins
  • CD4 Lymphocyte Count
  • Case-Control Studies
  • Cytotoxins
  • Female
  • HIV Seropositivity
  • Humans
  • Male
  • Pneumococcal Infections
  • Prospective Studies
  • Streptolysins
  • Substance-Related Disorders


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