Antioxidant treatment for heart failure: friend or foe

MJ Thomson, Michael Frenneaux, JC Kaski

Research output: Contribution to journalReview article

17 Citations (Scopus)


Increasing studies demonstrate a pivotal role for oxidant stress in the pathophysiology of heart failure (HF). Recent meta-analyses also reveal the potential pitfall of a mono-dimensional antioxidant approach. This review article summarizes the main biological pathways involved in oxidant stress and HF, the possible deleterious nature of certain antioxidant monotherapy and proposes potential antioxidant strategies necessary to challenge specific HF aetiology and progression.
Original languageEnglish
Pages (from-to)305-310
Number of pages6
Issue number5
Publication statusPublished - 1 May 2009


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