Abstract
The antimalarial agents NAS-91 and NAS-21 were found to express potent antimycobacterial activity, NAS-91 being more active than NAS-21. They partially inhibited mycolic acid biosynthesis and profoundly altered oleic acid production. The development of a cell-free assay for Delta 9-desaturase activity allowed direct demonstration of the inhibition of oleic acid biosynthesis by these compounds.
| Original language | English |
|---|---|
| Pages (from-to) | 1162-1166 |
| Number of pages | 5 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 52 |
| Issue number | 3 |
| Early online date | 17 Dec 2007 |
| DOIs | |
| Publication status | Published - 1 Mar 2008 |
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Dive into the research topics of 'Antimycobacterial activity and mechanism of action of NAS-91'. Together they form a unique fingerprint.Projects
- 1 Finished
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MAGPIE Project: The Structure and Assembly of the Mycobacterial Cell Envelope
Besra, D. (Principal Investigator), Lammas, T. (Co-Investigator) & Minnikin, D. (Co-Investigator)
1/02/06 → 31/01/11
Project: Research Councils
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