Antimicrobial resistance: a concise update

Charlotte S Ho; Carlos T H Wong; Thet Tun Aung; Rajamani Lakshminarayanan; Jodhbir S Mehta; Saaeha Rauz; Alan McNally; Balint Kintses; Sharon J Peacock; Cesar de la Fuente-Nunez; Robert E W Hancock; Darren S J Ting

doi:10.1016/j.lanmic.2024.07.010

Antimicrobial resistance: a concise update

Charlotte S Ho, Carlos T H Wong, Thet Tun Aung, Rajamani Lakshminarayanan, Jodhbir S Mehta, Saaeha Rauz, Alan McNally, Balint Kintses, Sharon J Peacock, Cesar de la Fuente-Nunez^*, Robert E W Hancock^*, Darren S J Ting^*

^*Corresponding author for this work

Inflammation and Ageing

Research output: Contribution to journal › Review article › peer-review

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Abstract

Antimicrobial resistance (AMR) is a serious threat to global public health, with approximately 5 million deaths associated with bacterial AMR in 2019. Tackling AMR requires a multifaceted and cohesive approach that ranges from increased understanding of mechanisms and drivers at the individual and population levels, AMR surveillance, antimicrobial stewardship, improved infection prevention and control measures, and strengthened global policies and funding to development of novel antimicrobial therapeutic strategies. In this rapidly advancing field, this Review provides a concise update on AMR, encompassing epidemiology, evolution, underlying mechanisms (primarily those related to last-line or newer generation of antibiotics), infection prevention and control measures, access to antibiotics, antimicrobial stewardship, AMR surveillance, and emerging non-antibiotic therapeutic approaches. The Review also discusses the potential roles of artificial intelligence in addressing AMR, including antimicrobial susceptibility testing, AMR surveillance, antimicrobial stewardship, diagnosis, and antimicrobial drug discovery and development. This Review highlights the urgent need for addressing the global effects of AMR and for rapid advancement of relevant technology in this dynamic field.

Original language	English
Article number	100947
Journal	The Lancet Microbe
Early online date	18 Sept 2024
DOIs	https://doi.org/10.1016/j.lanmic.2024.07.010
Publication status	E-pub ahead of print - 18 Sept 2024

Bibliographical note

Publisher Copyright:
© 2024 The Author(s)

ASJC Scopus subject areas

Microbiology
Microbiology (medical)
Infectious Diseases
Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.lanmic.2024.07.010Licence: Creative Commons: Attribution (CC BY)

HoC2024AntimicrobialProof, 1.1 MBLicence: Creative Commons: Attribution (CC BY)

1 Active
2 Finished

Impact of Oral Disulfiram on Aldehyde Dehydrogenase (ALDH) Mediated Ocular Fibrosis in Mucous Membrane Pemphigoid [OcMMP]
Barton, D. (Co-Investigator), Fletcher, P. (Co-Investigator), Rauz, S. (Principal Investigator), Low, L. (Co-Investigator), Romero, J. (Co-Investigator), Barnes, N. (Co-Investigator) & Wallace, G. (Co-Investigator)
Medical Research Council
1/10/23 → 31/05/26
Project: Research Councils
Fluid-Gels as Resorbable Protective Dressings for Ocular Surface Disease
Slade, A. (Co-Investigator), Rauz, S. (Principal Investigator) & Slade, A. (Co-Investigator)
NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE
1/03/19 → 30/09/24
Project: Other Government Departments
Development of a synthetic flowable dressing that prevents corneal scarring
Rauz, S. (Co-Investigator), Spyropoulos, F. (Co-Investigator), Barnes, N. (Co-Investigator), Billingham, L. (Co-Investigator), Wallace, G. (Co-Investigator), Grover, L. (Principal Investigator) & Logan, A. (Co-Investigator)
Medical Research Council
1/08/16 → 30/09/23
Project: Research Councils

Cite this

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title = "Antimicrobial resistance: a concise update",

abstract = "Antimicrobial resistance (AMR) is a serious threat to global public health, with approximately 5 million deaths associated with bacterial AMR in 2019. Tackling AMR requires a multifaceted and cohesive approach that ranges from increased understanding of mechanisms and drivers at the individual and population levels, AMR surveillance, antimicrobial stewardship, improved infection prevention and control measures, and strengthened global policies and funding to development of novel antimicrobial therapeutic strategies. In this rapidly advancing field, this Review provides a concise update on AMR, encompassing epidemiology, evolution, underlying mechanisms (primarily those related to last-line or newer generation of antibiotics), infection prevention and control measures, access to antibiotics, antimicrobial stewardship, AMR surveillance, and emerging non-antibiotic therapeutic approaches. The Review also discusses the potential roles of artificial intelligence in addressing AMR, including antimicrobial susceptibility testing, AMR surveillance, antimicrobial stewardship, diagnosis, and antimicrobial drug discovery and development. This Review highlights the urgent need for addressing the global effects of AMR and for rapid advancement of relevant technology in this dynamic field.",

author = "Ho, {Charlotte S} and Wong, {Carlos T H} and Aung, {Thet Tun} and Rajamani Lakshminarayanan and Mehta, {Jodhbir S} and Saaeha Rauz and Alan McNally and Balint Kintses and Peacock, {Sharon J} and {de la Fuente-Nunez}, Cesar and Hancock, {Robert E W} and Ting, {Darren S J}",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s)",

year = "2024",

month = sep,

day = "18",

doi = "10.1016/j.lanmic.2024.07.010",

language = "English",

journal = "The Lancet Microbe",

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T2 - a concise update

AU - Ho, Charlotte S

AU - Wong, Carlos T H

AU - Aung, Thet Tun

AU - Lakshminarayanan, Rajamani

AU - Mehta, Jodhbir S

AU - Rauz, Saaeha

AU - McNally, Alan

AU - Kintses, Balint

AU - Peacock, Sharon J

AU - de la Fuente-Nunez, Cesar

AU - Hancock, Robert E W

AU - Ting, Darren S J

PY - 2024/9/18

Y1 - 2024/9/18

N2 - Antimicrobial resistance (AMR) is a serious threat to global public health, with approximately 5 million deaths associated with bacterial AMR in 2019. Tackling AMR requires a multifaceted and cohesive approach that ranges from increased understanding of mechanisms and drivers at the individual and population levels, AMR surveillance, antimicrobial stewardship, improved infection prevention and control measures, and strengthened global policies and funding to development of novel antimicrobial therapeutic strategies. In this rapidly advancing field, this Review provides a concise update on AMR, encompassing epidemiology, evolution, underlying mechanisms (primarily those related to last-line or newer generation of antibiotics), infection prevention and control measures, access to antibiotics, antimicrobial stewardship, AMR surveillance, and emerging non-antibiotic therapeutic approaches. The Review also discusses the potential roles of artificial intelligence in addressing AMR, including antimicrobial susceptibility testing, AMR surveillance, antimicrobial stewardship, diagnosis, and antimicrobial drug discovery and development. This Review highlights the urgent need for addressing the global effects of AMR and for rapid advancement of relevant technology in this dynamic field.

AB - Antimicrobial resistance (AMR) is a serious threat to global public health, with approximately 5 million deaths associated with bacterial AMR in 2019. Tackling AMR requires a multifaceted and cohesive approach that ranges from increased understanding of mechanisms and drivers at the individual and population levels, AMR surveillance, antimicrobial stewardship, improved infection prevention and control measures, and strengthened global policies and funding to development of novel antimicrobial therapeutic strategies. In this rapidly advancing field, this Review provides a concise update on AMR, encompassing epidemiology, evolution, underlying mechanisms (primarily those related to last-line or newer generation of antibiotics), infection prevention and control measures, access to antibiotics, antimicrobial stewardship, AMR surveillance, and emerging non-antibiotic therapeutic approaches. The Review also discusses the potential roles of artificial intelligence in addressing AMR, including antimicrobial susceptibility testing, AMR surveillance, antimicrobial stewardship, diagnosis, and antimicrobial drug discovery and development. This Review highlights the urgent need for addressing the global effects of AMR and for rapid advancement of relevant technology in this dynamic field.

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U2 - 10.1016/j.lanmic.2024.07.010

DO - 10.1016/j.lanmic.2024.07.010

M3 - Review article

AN - SCOPUS:85205513015

SN - 2666-5247

JO - The Lancet Microbe

JF - The Lancet Microbe

M1 - 100947

ER -

Antimicrobial resistance: a concise update

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

Access to Document

Fingerprint

Projects

Impact of Oral Disulfiram on Aldehyde Dehydrogenase (ALDH) Mediated Ocular Fibrosis in Mucous Membrane Pemphigoid [OcMMP]

Fluid-Gels as Resorbable Protective Dressings for Ocular Surface Disease

Development of a synthetic flowable dressing that prevents corneal scarring

Cite this