Antibiotic entrapment in antibacterial micelles as a novel strategy for the delivery of challenging antibiotics from silica nanoparticles

Asier R. Muguruza, Maria L. Odyniec, Menisha Manhota, Zaina Habib, Knut Rurack, Jessica M.A. Blair, Sarah Kuehne, A. Damien Walmsley, Zoe Pikramenou*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

Silica materials are popular in biomedical applications as composites and drug delivery platforms due to their low toxicity and biocompatibility. Mesoporous silica nanoparticles are attractive drug delivery systems based on their porous silica framework with high surface area. In the preparation of mesoporous silica frameworks, most commonly, MCM-41, the efficient removal of the template responsible for introducing porous networks, cetyltrimethyl ammonium bromide (CTAB), is a critical step due to the template's high toxicity in the environment and human health. In this work, we present a new one-pot approach of introducing challenging antibiotics within a silica framework without the need of toxic templates, but instead using micelle formation by an antibacterial agent. We demonstrate that micelles formed by cetylpyridinium chloride (CPC), a known antibacterial agent, entrap antibiotics such as rifampicin and ciprofloxacin. Extensive NMR studies elucidate the precise localisation of the antibiotic within the CPC micelle. Ciprofloxacin is placed between the outer and palisade region while rifampicin is located further into the hydrophobic CPC micelle core. In both cases, the formation of the silica framework can be built around the CPC-antibiotic loaded micelles. The resulting silica nanoparticles show loading of both CPC and antibiotic agents, porosity and dual antibacterial release upon disruption of the micelle within the silica framework. The design not only provides a strategy of a therapeutic design to form porous frameworks but also highlights the potential of precise antibiotic dose and release in nanoparticle systems.
Original languageEnglish
Article number112841
Number of pages11
JournalMicroporous and Mesoporous Materials
Volume363
Early online date5 Oct 2023
DOIs
Publication statusPublished - 1 Jan 2024

Keywords

  • Cetylpyridinium chloride
  • Micelles
  • Nuclear magnetic resonance
  • Antibiotics
  • Porous silica nanoparticles
  • Drug delivery

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