Abstract
Drug efflux, unidirectional pumping of cytotoxic drugs, is a major mechanism of antimicrobial multiresistance in bacteria. Although these efflux systems are usually chromosomally encoded, some are present on plasmids. Some of the efflux pumps are relatively well known: Emr and Acr system in Escherichia coli, whose outer membrane protein seems to be the multifunctional To1C; the mex efflux system described in Pseudomonas aeruginosa and ABC-type in Gram-negative bacteria. Also the role of efflux in Gram-positive bacteria are reviewed including Bacillus, Staphylococcus and Streptomyces.
| Original language | English |
|---|---|
| Pages (from-to) | 285-300 |
| Number of pages | 16 |
| Journal | Microbiologia Espanola |
| Volume | 13 |
| Issue number | 3 |
| Publication status | Published - Sept 1997 |
Keywords
- ATP-Binding Cassette Transporters
- Bacterial Proteins
- Biological Transport, Active
- Carrier Proteins
- Chromosomes, Bacterial
- Drug Resistance, Microbial
- Drug Resistance, Multiple
- Escherichia coli
- Gram-Negative Bacteria
- Multigene Family
- Pseudomonas aeruginosa
- R Factors
- Tetracycline Resistance