Antibacterial efflux systems

N J Marshall, L J Piddock

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


Drug efflux, unidirectional pumping of cytotoxic drugs, is a major mechanism of antimicrobial multiresistance in bacteria. Although these efflux systems are usually chromosomally encoded, some are present on plasmids. Some of the efflux pumps are relatively well known: Emr and Acr system in Escherichia coli, whose outer membrane protein seems to be the multifunctional To1C; the mex efflux system described in Pseudomonas aeruginosa and ABC-type in Gram-negative bacteria. Also the role of efflux in Gram-positive bacteria are reviewed including Bacillus, Staphylococcus and Streptomyces.
Original languageEnglish
Pages (from-to)285-300
Number of pages16
JournalMicrobiologia Espanola
Issue number3
Publication statusPublished - Sept 1997


  • ATP-Binding Cassette Transporters
  • Bacterial Proteins
  • Biological Transport, Active
  • Carrier Proteins
  • Chromosomes, Bacterial
  • Drug Resistance, Microbial
  • Drug Resistance, Multiple
  • Escherichia coli
  • Gram-Negative Bacteria
  • Multigene Family
  • Pseudomonas aeruginosa
  • R Factors
  • Tetracycline Resistance


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