Anti-OX40 prevents effector T-cell accumulation and CD8+ T-cell mediated skin allograft rejection

Gillian Kinnear; Kathryn J Wood; Diane Marshall; Nicholas Jones

doi:10.1097/TP.0b013e3181fe5396

Anti-OX40 prevents effector T-cell accumulation and CD8+ T-cell mediated skin allograft rejection

Gillian Kinnear
, Kathryn J Wood
, Diane Marshall
, Nicholas Jones

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

376 Downloads (Pure)

Abstract

OX40 is a member of the tumor necrosis factor receptor superfamily and is a potent T-cell costimulatory molecule. Although the impact of blockade of the OX40-OX40L pathway has been documented in models of autoimmune disease, the effect on allograft rejection is less well defined.

Original language	English
Pages (from-to)	1265-71
Number of pages	7
Journal	Transplantation
Volume	90
Issue number	12
DOIs	https://doi.org/10.1097/TP.0b013e3181fe5396
Publication status	Published - 27 Dec 2010

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10.1097/TP.0b013e3181fe5396

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title = "Anti-OX40 prevents effector T-cell accumulation and CD8+ T-cell mediated skin allograft rejection",

abstract = "OX40 is a member of the tumor necrosis factor receptor superfamily and is a potent T-cell costimulatory molecule. Although the impact of blockade of the OX40-OX40L pathway has been documented in models of autoimmune disease, the effect on allograft rejection is less well defined.",

author = "Gillian Kinnear and Wood, \{Kathryn J\} and Diane Marshall and Nicholas Jones",

year = "2010",

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language = "English",

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T1 - Anti-OX40 prevents effector T-cell accumulation and CD8+ T-cell mediated skin allograft rejection

AU - Kinnear, Gillian

AU - Wood, Kathryn J

AU - Marshall, Diane

AU - Jones, Nicholas

PY - 2010/12/27

Y1 - 2010/12/27

N2 - OX40 is a member of the tumor necrosis factor receptor superfamily and is a potent T-cell costimulatory molecule. Although the impact of blockade of the OX40-OX40L pathway has been documented in models of autoimmune disease, the effect on allograft rejection is less well defined.

AB - OX40 is a member of the tumor necrosis factor receptor superfamily and is a potent T-cell costimulatory molecule. Although the impact of blockade of the OX40-OX40L pathway has been documented in models of autoimmune disease, the effect on allograft rejection is less well defined.

U2 - 10.1097/TP.0b013e3181fe5396

DO - 10.1097/TP.0b013e3181fe5396

M3 - Article

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VL - 90

SP - 1265

EP - 1271

JO - Transplantation

JF - Transplantation

IS - 12

ER -

Anti-OX40 prevents effector T-cell accumulation and CD8+ T-cell mediated skin allograft rejection

Abstract

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