Anti-endothelial cell autoantibodies and soluble markers of endothelial cell dysfunction in systemic lupus erythematosus

J Constans; R Dupuy; Andrew Blann; F Resplandy; M Seigneur; D Renard; M Longy-Boursier; T Schaeverbeke; V Guerin; MR Boisseau; C Conri

Anti-endothelial cell autoantibodies and soluble markers of endothelial cell dysfunction in systemic lupus erythematosus

J Constans, R Dupuy, Andrew Blann, F Resplandy, M Seigneur, D Renard, M Longy-Boursier, T Schaeverbeke, V Guerin, MR Boisseau, C Conri

Birmingham Medical School

Research output: Contribution to journal › Article

39 Citations (Scopus)

Abstract

OBJECTIVE: To determine if anti-endothelial cell antibodies (AECA) and plasma markers of endothelial cell function are related to disease severity in systemic lupus erythematosus (SLE). METHODS: We measured AECA by human umbilical vein endothelial cell binding, endothelial markers von Willebrand factor, soluble thrombomodulin, and soluble E-selectin by ELISA, and disease severity by SLEDAI and SLICC/ACR in 35 patients with SLE. RESULTS: Despite high levels of IgG AECA (p = 0.001) and von Willebrand factor (p = 0.0007) compared to 21 healthy controls, we found a positive correlation only between IgG AECA and the SLEDAI index (r = 0.393, p = 0.021). CONCLUSION: IgG AECA seem to be related to disease activity in SLE, possibly in a pathogenic role. Conversely, plasma markers of endothelial cell damage seem to be an epiphenomenon and may simply be related to excess inflammation.

Original language	English
Pages (from-to)	1963-1966
Number of pages	4
Journal	The Journal of Rheumatology
Volume	30
Publication status	Published - 1 Jan 2003

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{7c4245ba93494a2b86b76a31ce1d9f2b,

title = "Anti-endothelial cell autoantibodies and soluble markers of endothelial cell dysfunction in systemic lupus erythematosus",

abstract = "OBJECTIVE: To determine if anti-endothelial cell antibodies (AECA) and plasma markers of endothelial cell function are related to disease severity in systemic lupus erythematosus (SLE). METHODS: We measured AECA by human umbilical vein endothelial cell binding, endothelial markers von Willebrand factor, soluble thrombomodulin, and soluble E-selectin by ELISA, and disease severity by SLEDAI and SLICC/ACR in 35 patients with SLE. RESULTS: Despite high levels of IgG AECA (p = 0.001) and von Willebrand factor (p = 0.0007) compared to 21 healthy controls, we found a positive correlation only between IgG AECA and the SLEDAI index (r = 0.393, p = 0.021). CONCLUSION: IgG AECA seem to be related to disease activity in SLE, possibly in a pathogenic role. Conversely, plasma markers of endothelial cell damage seem to be an epiphenomenon and may simply be related to excess inflammation.",

author = "J Constans and R Dupuy and Andrew Blann and F Resplandy and M Seigneur and D Renard and M Longy-Boursier and T Schaeverbeke and V Guerin and MR Boisseau and C Conri",

year = "2003",

month = jan,

day = "1",

language = "English",

volume = "30",

pages = "1963--1966",

journal = "The Journal of Rheumatology",

publisher = "Journal of Rheumatology",

}

TY - JOUR

T1 - Anti-endothelial cell autoantibodies and soluble markers of endothelial cell dysfunction in systemic lupus erythematosus

AU - Constans, J

AU - Dupuy, R

AU - Blann, Andrew

AU - Resplandy, F

AU - Seigneur, M

AU - Renard, D

AU - Longy-Boursier, M

AU - Schaeverbeke, T

AU - Guerin, V

AU - Boisseau, MR

AU - Conri, C

PY - 2003/1/1

Y1 - 2003/1/1

N2 - OBJECTIVE: To determine if anti-endothelial cell antibodies (AECA) and plasma markers of endothelial cell function are related to disease severity in systemic lupus erythematosus (SLE). METHODS: We measured AECA by human umbilical vein endothelial cell binding, endothelial markers von Willebrand factor, soluble thrombomodulin, and soluble E-selectin by ELISA, and disease severity by SLEDAI and SLICC/ACR in 35 patients with SLE. RESULTS: Despite high levels of IgG AECA (p = 0.001) and von Willebrand factor (p = 0.0007) compared to 21 healthy controls, we found a positive correlation only between IgG AECA and the SLEDAI index (r = 0.393, p = 0.021). CONCLUSION: IgG AECA seem to be related to disease activity in SLE, possibly in a pathogenic role. Conversely, plasma markers of endothelial cell damage seem to be an epiphenomenon and may simply be related to excess inflammation.

AB - OBJECTIVE: To determine if anti-endothelial cell antibodies (AECA) and plasma markers of endothelial cell function are related to disease severity in systemic lupus erythematosus (SLE). METHODS: We measured AECA by human umbilical vein endothelial cell binding, endothelial markers von Willebrand factor, soluble thrombomodulin, and soluble E-selectin by ELISA, and disease severity by SLEDAI and SLICC/ACR in 35 patients with SLE. RESULTS: Despite high levels of IgG AECA (p = 0.001) and von Willebrand factor (p = 0.0007) compared to 21 healthy controls, we found a positive correlation only between IgG AECA and the SLEDAI index (r = 0.393, p = 0.021). CONCLUSION: IgG AECA seem to be related to disease activity in SLE, possibly in a pathogenic role. Conversely, plasma markers of endothelial cell damage seem to be an epiphenomenon and may simply be related to excess inflammation.

M3 - Article

C2 - 12966599

VL - 30

SP - 1963

EP - 1966

JO - The Journal of Rheumatology

JF - The Journal of Rheumatology

ER -

Anti-endothelial cell autoantibodies and soluble markers of endothelial cell dysfunction in systemic lupus erythematosus

Abstract

UN SDGs

Fingerprint

Cite this