Angiogenic factors in atrial fibrillation: a possible role in thrombogenesis?

Bethan Freestone, AY Chong, Hoong Lim, A Blann, Gregory Lip

Research output: Contribution to journalArticle

30 Citations (Scopus)


BACKGROUND: The precise pathophysiological processes underlying the prothrombotic or hypercoagulable state in atrial fibrillation (AF) remain uncertain. We hypothesized a relationship between abnormal endothelial damage/dysfunction, coagulation, and angiogenic factors, thereby contributing to increased thrombogenicity. METHODS: Plasma levels of von Willebrand factor (vWF, an index of endothelial damage/dysfunction) and tissue factor (TF, an index of coagulation), as well as the angiogenic factors, vascular endothelial growth factor (VEGF), angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2), were measured by enzyme-linked immunosorbant assay (ELISA) in 59 chronic AF patients. Data were compared to 40 age- and sex-matched healthy controls in sinus rhythm. RESULTS: Plasma vWF, VEGF and Ang-2 were significantly higher in AF patients compared to healthy controls (P=0.005, P=0.0055 and P
Original languageEnglish
Pages (from-to)365-72
Number of pages8
JournalAnnals of Medicine
Issue number5
Publication statusPublished - 1 Jan 2005


  • angiopoietin
  • endothelium
  • vascular endothelial growth factor
  • tissue factor


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