Angiogenic Activity of Dentin Matrix Components

R Zhang, Paul Cooper, Gay Smith, JE Noer, Anthony Smith

Research output: Contribution to journalArticle

70 Citations (Scopus)


Angiogenesis is key to both the development and regeneration of the dentin-pulp complex. Objective: We hypothesized that proangiogenic signaling molecules sequestered in dentin matrix can be solubilised to induce angiogenic events. Methods: Matrix components were extracted from powdered sound human dentin with EDTA and their dose-dependent (0.0001-5 mg/mL) effects examined in endothelial cells in an in vitro angiogenic tube formation assay, proliferation assay, and transcriptional regulation of the VEGF and VEGF-R2 genes. Results: Lower concentrations of dentin matrix components were found to show proangiogenic activity, whereas higher concentrations suppressed angiogenic activity. Conclusion: This study highlights that the release of dentin matrix components after dental injury can contribute to the angiogenic events that support pulp regeneration. (J Endod 2011;37:26-30)
Original languageEnglish
Pages (from-to)26-30
Number of pages5
JournalJournal of Endodontics
Issue number1
Publication statusPublished - 1 Jan 2011


  • dentin
  • revascularization
  • regeneration
  • stem cells
  • Angiogenesis
  • endodontics
  • growth factors


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