Analysis of incisor cell populations in Wistar rats of different ages

Peter Murray, John Matthews, Alastair Sloan, Anthony Smith

Research output: Contribution to journalArticle

28 Citations (Scopus)


Pulp cell function and viability is important for maintaining tooth vitality throughout life. However, the effects of ageing on pulpal cell populations and pulp tissue remodelling are still unclear. The aim here was to quantify age-related cell-density changes in the pulp of rat incisor teeth, using histomorphometric analysis and ANOVA. Mandibular (n=35) and maxillary (n=34) incisors were carefully extracted from 20 Wistar rats aged between 1 and 18 months, fixed and processed for light microscopy. Cell counts were performed in mature and immature regions at both labial and lingual aspects of all teeth. Odontoblast and subodontoblast cell densities were reported per mm of pulp-dentine border and core fibroblast density per mm2 pulp tissue. Irrespective of age, odontoblast and subodontoblast densities were lower in the immature than the mature regions of both maxillary and mandibular incisors (P
Original languageEnglish
Pages (from-to)709-715
Number of pages7
JournalArchives of Oral Biology
Issue number10
Publication statusPublished - 1 Oct 2002


  • odontoblasts
  • fibroblasts
  • ageing
  • dentine
  • tooth pulp


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