Analysis of bone formation after sinus augmentation using β-tricalcium phosphate

Ulrike Schulze-Späte, Thomas Dietrich, Rayyan A Kayal, Hatice Hasturk, Justine Dobeck, Ziedonis Skobe, Serge Dibart

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Implant placement in the edentulous maxilla often represents a clinical challenge due to insufficient bone height after crestal bone resorption and maxillary sinus pneumatization. Several graft materials have been evaluated for augmenting the maxillary sinus to compensate for the lost vertical dimension. Allografts are readily available without the risk of disease transmission and the need for a second site surgery. The aim of this case series was to systematically evaluate the development and maturation of augmented bone in the maxillary sinus using beta-tricalcium phosphate. In 21 to 40 weeks post-sinus elevation, bone biopsies were taken and implants placed simultaneously. All specimens were demineralized and subjected to staining procedures (ie, Hematoxylin and Eosin [H&E], Goldner's staining, and tartrate-resistant acid phosphatase [TRAP]). Total bone increased over time, whereas the amount of graft material diminished. A lack of inflammatory reaction was noticed with the use of this graft material. In addition, TRAP staining revealed the presence of osteoclasts surrounding the remaining particles. During a 12-month follow-up, no implant failure or complications were observed.

Original languageEnglish
Pages (from-to)364-8
Number of pages5
JournalCompendium of continuing education in dentistry
Issue number5
Publication statusPublished - May 2012


  • Absorbable Implants
  • Acid Phosphatase
  • Adult
  • Aged
  • Biomarkers
  • Biopsy
  • Bone Substitutes
  • Calcium Phosphates
  • Collagen
  • Coloring Agents
  • Dental Implantation, Endosseous
  • Female
  • Follow-Up Studies
  • Humans
  • Isoenzymes
  • Male
  • Maxilla
  • Maxillary Sinus
  • Membranes, Artificial
  • Middle Aged
  • Osseointegration
  • Osteoclasts
  • Osteogenesis
  • Sinus Floor Augmentation


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