An optofluidic Young interferometer sensor for real-time imaging of refractive index in μTAS applications

Ruchi Gupta; Elisabetta Labella; Nicholas J. Goddard

doi:10.1016/j.snb.2020.128491

An optofluidic Young interferometer sensor for real-time imaging of refractive index in μTAS applications

Ruchi Gupta, Elisabetta Labella, Nicholas J. Goddard

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

This report describes a Young interferometer (YI) sensor for real-time imaging of refractive index (RI) along the length of microchannels. The YI comprised a unique combination of Fresnel biprism and cylindrical lens to obtain two wedge shaped light beams, which ultimately overlapped to produce the interference fringes. The measured temporal and spatial resolution of the reported YI is 2 s and 295 μm respectively. The RI resolution per mm of the optical pathlength of the YI sensor is 2.04 × 10 ⁻⁶ while providing information on spatial RI distribution in real-time. The ability of the reported YI to image RI in real-time was used to monitor electrokinetic transport of a model protein, bovine serum albumin (BSA), in agarose filled channels of a microfluidic device. This method is particularly suitable to planar μTAS devices as it is free-space, senses through the entire depth of the channel and requires no coupling devices such as gratings or prisms.

Original language	English
Article number	128491
Journal	Sensors and Actuators B: Chemical
Volume	321
DOIs	https://doi.org/10.1016/j.snb.2020.128491
Publication status	Published - Oct 2020

Bibliographical note

Funding Information:
RG acknowledges the funding support from the Engineering and Physical Sciences Research Council (Grant EP/N02074X/2 ) and University of Birmingham .

Publisher Copyright:
© 2020 Elsevier B.V.

Keywords

Bovine serum albumin
Imaging
Optofluidic
Refractive index
Sensor
Young interferometer

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering
Materials Chemistry

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10.1016/j.snb.2020.128491

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@article{2d3421912e7a45cc86b66c5ae2613de5,

title = "An optofluidic Young interferometer sensor for real-time imaging of refractive index in μTAS applications",

abstract = "This report describes a Young interferometer (YI) sensor for real-time imaging of refractive index (RI) along the length of microchannels. The YI comprised a unique combination of Fresnel biprism and cylindrical lens to obtain two wedge shaped light beams, which ultimately overlapped to produce the interference fringes. The measured temporal and spatial resolution of the reported YI is 2 s and 295 μm respectively. The RI resolution per mm of the optical pathlength of the YI sensor is 2.04 × 10 −6 while providing information on spatial RI distribution in real-time. The ability of the reported YI to image RI in real-time was used to monitor electrokinetic transport of a model protein, bovine serum albumin (BSA), in agarose filled channels of a microfluidic device. This method is particularly suitable to planar μTAS devices as it is free-space, senses through the entire depth of the channel and requires no coupling devices such as gratings or prisms. ",

keywords = "Bovine serum albumin, Imaging, Optofluidic, Refractive index, Sensor, Young interferometer",

author = "Ruchi Gupta and Elisabetta Labella and Goddard, {Nicholas J.}",

note = "Funding Information: RG acknowledges the funding support from the Engineering and Physical Sciences Research Council (Grant EP/N02074X/2 ) and University of Birmingham . Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",

year = "2020",

month = oct,

doi = "10.1016/j.snb.2020.128491",

language = "English",

volume = "321",

journal = "Sensors and Actuators B: Chemical",

issn = "0925-4005",

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T1 - An optofluidic Young interferometer sensor for real-time imaging of refractive index in μTAS applications

AU - Gupta, Ruchi

AU - Labella, Elisabetta

AU - Goddard, Nicholas J.

N1 - Funding Information: RG acknowledges the funding support from the Engineering and Physical Sciences Research Council (Grant EP/N02074X/2 ) and University of Birmingham . Publisher Copyright: © 2020 Elsevier B.V.

PY - 2020/10

Y1 - 2020/10

N2 - This report describes a Young interferometer (YI) sensor for real-time imaging of refractive index (RI) along the length of microchannels. The YI comprised a unique combination of Fresnel biprism and cylindrical lens to obtain two wedge shaped light beams, which ultimately overlapped to produce the interference fringes. The measured temporal and spatial resolution of the reported YI is 2 s and 295 μm respectively. The RI resolution per mm of the optical pathlength of the YI sensor is 2.04 × 10 −6 while providing information on spatial RI distribution in real-time. The ability of the reported YI to image RI in real-time was used to monitor electrokinetic transport of a model protein, bovine serum albumin (BSA), in agarose filled channels of a microfluidic device. This method is particularly suitable to planar μTAS devices as it is free-space, senses through the entire depth of the channel and requires no coupling devices such as gratings or prisms.

AB - This report describes a Young interferometer (YI) sensor for real-time imaging of refractive index (RI) along the length of microchannels. The YI comprised a unique combination of Fresnel biprism and cylindrical lens to obtain two wedge shaped light beams, which ultimately overlapped to produce the interference fringes. The measured temporal and spatial resolution of the reported YI is 2 s and 295 μm respectively. The RI resolution per mm of the optical pathlength of the YI sensor is 2.04 × 10 −6 while providing information on spatial RI distribution in real-time. The ability of the reported YI to image RI in real-time was used to monitor electrokinetic transport of a model protein, bovine serum albumin (BSA), in agarose filled channels of a microfluidic device. This method is particularly suitable to planar μTAS devices as it is free-space, senses through the entire depth of the channel and requires no coupling devices such as gratings or prisms.

KW - Bovine serum albumin

KW - Imaging

KW - Optofluidic

KW - Refractive index

KW - Sensor

KW - Young interferometer

UR - https://doi.org/10.1016/j.snb.2020.128491

U2 - 10.1016/j.snb.2020.128491

DO - 10.1016/j.snb.2020.128491

M3 - Article

SN - 0925-4005

VL - 321

JO - Sensors and Actuators B: Chemical

JF - Sensors and Actuators B: Chemical

M1 - 128491

ER -

An optofluidic Young interferometer sensor for real-time imaging of refractive index in μTAS applications

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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