An Observational Study of Social Interaction Skills and Behaviors in Cornelia de Lange, Fragile X and Rubinstein-Taybi Syndromes

Katherine Ellis, Chris Oliver, Chrysi Stefanidou, Ian Apperly, Jo Moss

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Abstract

We directly assessed the broader aspects of sociability (social enjoyment, social motivation, social interaction skills and social discomfort) in individuals with Cornelia de Lange (CdLS), fragile X (FXS) and Rubinstein-Taybi syndromes (RTS), and their association with autism characteristics and chronological age in these groups. Individuals with FXS (p < 0.01) and RTS (p < 0.01) showed poorer quality of eye contact compared to individuals with CdLS. Individuals with FXS showed less person and more object attention than individuals with CdLS (p < 0.01). Associations between sociability and autism characteristics and chronological age differed between groups, which may indicate divergence in the development and aetiology of different components of sociability across these groups. Findings indicate that individuals with CdLS, FXS and RTS show unique profiles of sociability.

Original languageEnglish
JournalJournal of Autism and Developmental Disorders
Early online date18 Mar 2020
DOIs
Publication statusE-pub ahead of print - 18 Mar 2020

Keywords

  • Eye gaze
  • Fragile X syndrome
  • Genetics behavioural
  • Neurodevelopmental disorders
  • Social behavior

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