An observational study of endothelial function in early arthritis.

W Foster, Gregory Lip, Karim Raza, David Carruthers, Andrew Blann

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22 Citations (Scopus)
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Eur J Clin Invest 2011 ABSTRACT: Background  Endothelial dysfunction is present in established rheumatoid arthritis, but it is not clear at what stage of the disease this abnormality develops. We set out to determine whether endothelial damage/dysfunction is present in a group of patients with early arthritis (EA) (new onset inflammatory arthritis, EA). Materials and methods  Eighteen patients with EA, 48 healthy controls and 25 disease controls were recruited. Plasma was obtained for endothelial [von Willebrand factor (vWF) and soluble E-selectin] and angiogenesis markers (vascular endothelial growth factor and its receptor sFlt-1), adhesion molecules (intercellular adhesion molecule 1 and vascular cell adhesion molecule 1) and circulating endothelial cells (CECs, as a marker of endothelial damage). Microvascular endothelial function was assessed using laser Doppler perfusion imaging and macrovascular function using flow-mediated dilatation of the brachial artery. Results  von Willebrand factor and CECs (both P 
Original languageEnglish
Pages (from-to)510-516
JournalEuropean journal of clinical investigation
Issue number5
Early online date10 Oct 2011
Publication statusPublished - May 2012


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