Abstract
A synthetic route to a new class of privileged tri- and tetra-cyclic quinazolines containing a medium-sized ring is reported. An expedient synthetic route involving nucleophilic aromatic substitution, and sequential Niementowski and BOP-mediated ring closures afforded a collection of analogues. The scope of the reaction was explored in terms of cyclic and acyclic linkers, ring size and substitution pattern.
Original language | English |
---|---|
Pages (from-to) | 6478-6483 |
Number of pages | 6 |
Journal | Tetrahedron Letters |
Volume | 56 |
Issue number | 46 |
Early online date | 9 Oct 2015 |
DOIs | |
Publication status | Published - 18 Nov 2015 |
Keywords
- Cyclisation
- Heterocycle
- Medium-ring
- Niementowski reaction
- Quinazoline