An expedient synthesis of oxazepino and oxazocino quinazolines

Albertus Wijnand Hensbergen, Vanessa R. Mills, Ian Collins, Alan M. Jones

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


A synthetic route to a new class of privileged tri- and tetra-cyclic quinazolines containing a medium-sized ring is reported. An expedient synthetic route involving nucleophilic aromatic substitution, and sequential Niementowski and BOP-mediated ring closures afforded a collection of analogues. The scope of the reaction was explored in terms of cyclic and acyclic linkers, ring size and substitution pattern.
Original languageEnglish
Pages (from-to)6478-6483
Number of pages6
JournalTetrahedron Letters
Issue number46
Early online date9 Oct 2015
Publication statusPublished - 18 Nov 2015


  • Cyclisation
  • Heterocycle
  • Medium-ring
  • Niementowski reaction
  • Quinazoline


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