An association of craniopharyngioma in Turner syndrome

Aqeel Farooque; Navoda Atapattu; Sujeewa Amarasena; Wolfgang Högler; Martin W English; Jeremy M W Kirk

doi:10.1002/pbc.24411

An association of craniopharyngioma in Turner syndrome

Aqeel Farooque, Navoda Atapattu, Sujeewa Amarasena, Wolfgang Högler, Martin W English, Jeremy M W Kirk

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Turner syndrome (TS) (approximately 1:5,000 births) and craniopharyngioma (CP) (1:50,000 children) are both rare conditions. We present three cases of TS with CP, an association not previously described. Visual failure, poor growth or headache led to MRI diagnosis of CP. Whilst two had evidence of hypopituitarism at diagnosis of CP, they all developed hypopituitarism following surgical debulking. Two required radiotherapy due to regrowth. Whether CP and TS share a similar aetiology is unknown. Clinicians need to be aware of this association, and should perform urgent MRI scanning in TS patients with headache, visual impairment or clinical/biochemical evidence of hypopituitarism.

Original language	English
Pages (from-to)	E7-9
Journal	Pediatric Blood & Cancer
Volume	60
Issue number	6
DOIs	https://doi.org/10.1002/pbc.24411
Publication status	Published - Jun 2013

Keywords

Adolescent
Child, Preschool
Craniopharyngioma
Female
Humans
Pituitary Neoplasms
Turner Syndrome
Case Reports
Journal Article

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10.1002/pbc.24411

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title = "An association of craniopharyngioma in Turner syndrome",

abstract = "Turner syndrome (TS) (approximately 1:5,000 births) and craniopharyngioma (CP) (1:50,000 children) are both rare conditions. We present three cases of TS with CP, an association not previously described. Visual failure, poor growth or headache led to MRI diagnosis of CP. Whilst two had evidence of hypopituitarism at diagnosis of CP, they all developed hypopituitarism following surgical debulking. Two required radiotherapy due to regrowth. Whether CP and TS share a similar aetiology is unknown. Clinicians need to be aware of this association, and should perform urgent MRI scanning in TS patients with headache, visual impairment or clinical/biochemical evidence of hypopituitarism.",

keywords = "Adolescent, Child, Preschool, Craniopharyngioma, Female, Humans, Pituitary Neoplasms, Turner Syndrome, Case Reports, Journal Article",

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T1 - An association of craniopharyngioma in Turner syndrome

AU - Farooque, Aqeel

AU - Atapattu, Navoda

AU - Amarasena, Sujeewa

AU - Högler, Wolfgang

AU - English, Martin W

AU - Kirk, Jeremy M W

PY - 2013/6

Y1 - 2013/6

N2 - Turner syndrome (TS) (approximately 1:5,000 births) and craniopharyngioma (CP) (1:50,000 children) are both rare conditions. We present three cases of TS with CP, an association not previously described. Visual failure, poor growth or headache led to MRI diagnosis of CP. Whilst two had evidence of hypopituitarism at diagnosis of CP, they all developed hypopituitarism following surgical debulking. Two required radiotherapy due to regrowth. Whether CP and TS share a similar aetiology is unknown. Clinicians need to be aware of this association, and should perform urgent MRI scanning in TS patients with headache, visual impairment or clinical/biochemical evidence of hypopituitarism.

AB - Turner syndrome (TS) (approximately 1:5,000 births) and craniopharyngioma (CP) (1:50,000 children) are both rare conditions. We present three cases of TS with CP, an association not previously described. Visual failure, poor growth or headache led to MRI diagnosis of CP. Whilst two had evidence of hypopituitarism at diagnosis of CP, they all developed hypopituitarism following surgical debulking. Two required radiotherapy due to regrowth. Whether CP and TS share a similar aetiology is unknown. Clinicians need to be aware of this association, and should perform urgent MRI scanning in TS patients with headache, visual impairment or clinical/biochemical evidence of hypopituitarism.

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KW - Child, Preschool

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KW - Female

KW - Humans

KW - Pituitary Neoplasms

KW - Turner Syndrome

KW - Case Reports

KW - Journal Article

U2 - 10.1002/pbc.24411

DO - 10.1002/pbc.24411

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VL - 60

SP - E7-9

JO - Pediatric Blood & Cancer

JF - Pediatric Blood & Cancer

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An association of craniopharyngioma in Turner syndrome

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