TY - JOUR
T1 - Amino acid-modified spray-dried powders with enhanced aerosolisation properties for pulmonary drug delivery
AU - Seville, P.C.
AU - Learoyd, T.P.
AU - Li, H.-Y.
AU - Birchall, J.C.
AU - Williamson, I.J.
PY - 2007/9/5
Y1 - 2007/9/5
N2 - In this study, the amino acids arginine, aspartic acid, leucine, phenylalanine and threonine were investigated as 'dispersibility enhancers' in spray-dried powders for inhalation. Parameters such as spray-dried yield, tapped density, and Carr's Index were not predictive of aerosolisation performance. In addition, whilst the majority of amino acid-modified powders displayed suitable particle size distribution for pulmonary administration and potentially favourable low moisture content, in vitro particle deposition was only enhanced for the leucine-modified powder. In summary, leucine can be used to enhance the dispersibility and aerosolisation properties of spray-dried powders for pulmonary drug delivery.
AB - In this study, the amino acids arginine, aspartic acid, leucine, phenylalanine and threonine were investigated as 'dispersibility enhancers' in spray-dried powders for inhalation. Parameters such as spray-dried yield, tapped density, and Carr's Index were not predictive of aerosolisation performance. In addition, whilst the majority of amino acid-modified powders displayed suitable particle size distribution for pulmonary administration and potentially favourable low moisture content, in vitro particle deposition was only enhanced for the leucine-modified powder. In summary, leucine can be used to enhance the dispersibility and aerosolisation properties of spray-dried powders for pulmonary drug delivery.
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-34547841357&partnerID=8YFLogxK
U2 - 10.1016/j.powtec.2007.03.046
DO - 10.1016/j.powtec.2007.03.046
M3 - Article
AN - SCOPUS:34547841357
SN - 0032-5910
VL - 178
SP - 40
EP - 50
JO - Powder Technology
JF - Powder Technology
IS - 1
ER -