Altered SMRT levels disrupt vitamin D3 receptor signalling in prostate cancer cells

Farhat Khanim; Lyndon Gommersall; Victoria Wood; KL Smith; L Montalvo; Laura O'Neill; Y Xu; DM Peehl; Paul Stewart; Bryan Turner; Moray Campbell

doi:10.1038/sj.onc.1207772

Altered SMRT levels disrupt vitamin D3 receptor signalling in prostate cancer cells

Farhat Khanim, Lyndon Gommersall, Victoria Wood, KL Smith, L Montalvo, Laura O'Neill, Y Xu, DM Peehl, Paul Stewart, Bryan Turner, Moray Campbell

Research output: Contribution to journal › Article

107 Citations (Scopus)

Abstract

We hypothesized that key antiproliferative target genes for the vitamin D receptor (VDR) were repressed by an epigenetic mechanism in prostate cancer cells resulting in apparent hormonal insensitivity. To explore this possibility, we examined nuclear receptor corepressor expression in a panel of nonmalignant and malignant cell lines and primary cultures, and found frequently elevated SMRT corepressor mRNA expression often associated with reduced sensitivity to 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)2D3). For example, PC-3 and DU-145 prostate cancer cell lines had 1.8-fold and twofold increases in SMRT mRNA relative to normal PrEC cells (P

Original language	English
Pages (from-to)	6712-25
Number of pages	14
Journal	Oncogene
Volume	23
Issue number	40
Early online date	9 Aug 2004
DOIs	https://doi.org/10.1038/sj.onc.1207772
Publication status	Published - 2 Sept 2004

Bibliographical note

PubMed publication date shown as September 2004.

Keywords

1 alpha,25-dihydroxyvitamin D-3
histone deacetylation inhibitors
prostate cancer
SMRT
GADD45 alpha

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/sj.onc.1207772Licence: None: All rights reserved

Cite this

@article{c7b3b0518b784fbfb3b7718931d309cd,

title = "Altered SMRT levels disrupt vitamin D3 receptor signalling in prostate cancer cells",

abstract = "We hypothesized that key antiproliferative target genes for the vitamin D receptor (VDR) were repressed by an epigenetic mechanism in prostate cancer cells resulting in apparent hormonal insensitivity. To explore this possibility, we examined nuclear receptor corepressor expression in a panel of nonmalignant and malignant cell lines and primary cultures, and found frequently elevated SMRT corepressor mRNA expression often associated with reduced sensitivity to 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)2D3). For example, PC-3 and DU-145 prostate cancer cell lines had 1.8-fold and twofold increases in SMRT mRNA relative to normal PrEC cells (P",

keywords = "1 alpha,25-dihydroxyvitamin D-3, histone deacetylation inhibitors, prostate cancer, SMRT, GADD45 alpha",

author = "Farhat Khanim and Lyndon Gommersall and Victoria Wood and KL Smith and L Montalvo and Laura O'Neill and Y Xu and DM Peehl and Paul Stewart and Bryan Turner and Moray Campbell",

note = "PubMed publication date shown as September 2004.",

year = "2004",

month = sep,

day = "2",

doi = "10.1038/sj.onc.1207772",

language = "English",

volume = "23",

pages = "6712--25",

journal = "Oncogene",

publisher = "Nature Publishing Group",

number = "40",

}

TY - JOUR

T1 - Altered SMRT levels disrupt vitamin D3 receptor signalling in prostate cancer cells

AU - Khanim, Farhat

AU - Gommersall, Lyndon

AU - Wood, Victoria

AU - Smith, KL

AU - Montalvo, L

AU - O'Neill, Laura

AU - Xu, Y

AU - Peehl, DM

AU - Stewart, Paul

AU - Turner, Bryan

AU - Campbell, Moray

N1 - PubMed publication date shown as September 2004.

PY - 2004/9/2

Y1 - 2004/9/2

N2 - We hypothesized that key antiproliferative target genes for the vitamin D receptor (VDR) were repressed by an epigenetic mechanism in prostate cancer cells resulting in apparent hormonal insensitivity. To explore this possibility, we examined nuclear receptor corepressor expression in a panel of nonmalignant and malignant cell lines and primary cultures, and found frequently elevated SMRT corepressor mRNA expression often associated with reduced sensitivity to 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)2D3). For example, PC-3 and DU-145 prostate cancer cell lines had 1.8-fold and twofold increases in SMRT mRNA relative to normal PrEC cells (P

AB - We hypothesized that key antiproliferative target genes for the vitamin D receptor (VDR) were repressed by an epigenetic mechanism in prostate cancer cells resulting in apparent hormonal insensitivity. To explore this possibility, we examined nuclear receptor corepressor expression in a panel of nonmalignant and malignant cell lines and primary cultures, and found frequently elevated SMRT corepressor mRNA expression often associated with reduced sensitivity to 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)2D3). For example, PC-3 and DU-145 prostate cancer cell lines had 1.8-fold and twofold increases in SMRT mRNA relative to normal PrEC cells (P

KW - 1 alpha,25-dihydroxyvitamin D-3

KW - histone deacetylation inhibitors

KW - prostate cancer

KW - SMRT

KW - GADD45 alpha

UR - http://www.scopus.com/inward/record.url?scp=4644309396&partnerID=8YFLogxK

U2 - 10.1038/sj.onc.1207772

DO - 10.1038/sj.onc.1207772

M3 - Article

C2 - 15300237

VL - 23

SP - 6712

EP - 6725

JO - Oncogene

JF - Oncogene

IS - 40

ER -

Altered SMRT levels disrupt vitamin D3 receptor signalling in prostate cancer cells

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this