Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma

C Ludwig; D S Williams; D B Bartlett; S J Essex; G McNee; J W Allwood; E Jewell; A Barkhuisen; H Parry; S Anandram; P Nicolson; C Gardener; F Seymour; S Basu; W B Dunn; P A H Moss; G Pratt; D A Tennant

doi:10.1038/bcj.2015.85

Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma

C Ludwig, D S Williams, D B Bartlett, S J Essex, G McNee, J W Allwood, E Jewell, A Barkhuisen, H Parry, S Anandram, P Nicolson, C Gardener, F Seymour, S Basu, W B Dunn, P A H Moss, G Pratt, D A Tennant

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Abstract

Multiple myeloma (MM) is a malignant disorder of plasma cells arising from a clinically benign state known as monoclonal gammopathy of undetermined significance (MGUS). The biological mechanisms for disease progression are not well understood. As acquisition of malignant phenotypes by a tumour is often associated with metabolic transformation, the cancer metabolome may act as a dynamic read-out of its phenotype. The aim of this investigation was therefore to characterise the metabolic profile within the bone marrow of healthy donors and patients with MGUS or MM, and to determine if any observed differences between these disorders could be observed within peripheral plasma.

Original language	English
Article number	e359
Journal	Blood Cancer Journal
Volume	5
DOIs	https://doi.org/10.1038/bcj.2015.85
Publication status	Published - 16 Oct 2015

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10.1038/bcj.2015.85Licence: Creative Commons: Attribution (CC BY)

Ludwig_et_al_2015_Alterations_bone_marrow_Blood_Cancer_Journal
Eligibility for repository : checked 16/10/2015
Final published version, 1.2 MBLicence: Creative Commons: Attribution (CC BY)

Investigating the role of the mesenchymal stem cell phenotype in the pathogenesis of multiple myeloma
Tennant, D. (Principal Investigator), Pratt, G. (Co-Investigator) & Ludwig, C. (Co-Investigator)
BLOODWISE
6/01/14 → 5/05/17
Project: Research
HWB:NMR: a national resource for biomolecular research
Overduin, M. (Principal Investigator), Guenther, U. (Co-Investigator), Ludwig, C. (Co-Investigator), Arvanitis, T. (Co-Investigator), Dafforn, T. (Co-Investigator), Hyde, E. (Co-Investigator), Levine, B. (Co-Investigator), Peet, A. (Co-Investigator) & Viant, M. (Co-Investigator)
Wellcome Trust
1/12/12 → 28/02/18
Project: Research

Cite this

Ludwig, C., Williams, D. S., Bartlett, D. B., Essex, S. J., McNee, G., Allwood, J. W., Jewell, E., Barkhuisen, A., Parry, H., Anandram, S., Nicolson, P., Gardener, C., Seymour, F., Basu, S., Dunn, W. B., Moss, P. A. H., Pratt, G., & Tennant, D. A. (2015). Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma. Blood Cancer Journal, 5, Article e359. https://doi.org/10.1038/bcj.2015.85

@article{464df6d55f294f199610c8a9f7f36f74,

title = "Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma",

abstract = "Multiple myeloma (MM) is a malignant disorder of plasma cells arising from a clinically benign state known as monoclonal gammopathy of undetermined significance (MGUS). The biological mechanisms for disease progression are not well understood. As acquisition of malignant phenotypes by a tumour is often associated with metabolic transformation, the cancer metabolome may act as a dynamic read-out of its phenotype. The aim of this investigation was therefore to characterise the metabolic profile within the bone marrow of healthy donors and patients with MGUS or MM, and to determine if any observed differences between these disorders could be observed within peripheral plasma. ",

author = "C Ludwig and Williams, {D S} and Bartlett, {D B} and Essex, {S J} and G McNee and Allwood, {J W} and E Jewell and A Barkhuisen and H Parry and S Anandram and P Nicolson and C Gardener and F Seymour and S Basu and Dunn, {W B} and Moss, {P A H} and G Pratt and Tennant, {D A}",

year = "2015",

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day = "16",

doi = "10.1038/bcj.2015.85",

language = "English",

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journal = "Blood Cancer Journal",

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Ludwig, C, Williams, DS, Bartlett, DB, Essex, SJ, McNee, G, Allwood, JW, Jewell, E, Barkhuisen, A, Parry, H, Anandram, S, Nicolson, P, Gardener, C, Seymour, F, Basu, S, Dunn, WB, Moss, PAH, Pratt, G & Tennant, DA 2015, 'Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma', Blood Cancer Journal, vol. 5, e359. https://doi.org/10.1038/bcj.2015.85

TY - JOUR

T1 - Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma

AU - Ludwig, C

AU - Williams, D S

AU - Bartlett, D B

AU - Essex, S J

AU - McNee, G

AU - Allwood, J W

AU - Jewell, E

AU - Barkhuisen, A

AU - Parry, H

AU - Anandram, S

AU - Nicolson, P

AU - Gardener, C

AU - Seymour, F

AU - Basu, S

AU - Dunn, W B

AU - Moss, P A H

AU - Pratt, G

AU - Tennant, D A

PY - 2015/10/16

Y1 - 2015/10/16

N2 - Multiple myeloma (MM) is a malignant disorder of plasma cells arising from a clinically benign state known as monoclonal gammopathy of undetermined significance (MGUS). The biological mechanisms for disease progression are not well understood. As acquisition of malignant phenotypes by a tumour is often associated with metabolic transformation, the cancer metabolome may act as a dynamic read-out of its phenotype. The aim of this investigation was therefore to characterise the metabolic profile within the bone marrow of healthy donors and patients with MGUS or MM, and to determine if any observed differences between these disorders could be observed within peripheral plasma.

AB - Multiple myeloma (MM) is a malignant disorder of plasma cells arising from a clinically benign state known as monoclonal gammopathy of undetermined significance (MGUS). The biological mechanisms for disease progression are not well understood. As acquisition of malignant phenotypes by a tumour is often associated with metabolic transformation, the cancer metabolome may act as a dynamic read-out of its phenotype. The aim of this investigation was therefore to characterise the metabolic profile within the bone marrow of healthy donors and patients with MGUS or MM, and to determine if any observed differences between these disorders could be observed within peripheral plasma.

U2 - 10.1038/bcj.2015.85

DO - 10.1038/bcj.2015.85

M3 - Letter

C2 - 26473531

SN - 2044-5385

VL - 5

JO - Blood Cancer Journal

JF - Blood Cancer Journal

M1 - e359

ER -

Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma

Abstract

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Projects

Investigating the role of the mesenchymal stem cell phenotype in the pathogenesis of multiple myeloma

HWB:NMR: a national resource for biomolecular research

Cite this