Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma

C Ludwig, D S Williams, D B Bartlett, S J Essex, G McNee, J W Allwood, E Jewell, A Barkhuisen, H Parry, S Anandram, P Nicolson, C Gardener, F Seymour, S Basu, W B Dunn, P A H Moss, G Pratt, D A Tennant

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Abstract

Multiple myeloma (MM) is a malignant disorder of plasma cells arising from a clinically benign state known as monoclonal gammopathy of undetermined significance (MGUS). The biological mechanisms for disease progression are not well understood. As acquisition of malignant phenotypes by a tumour is often associated with metabolic transformation, the cancer metabolome may act as a dynamic read-out of its phenotype. The aim of this investigation was therefore to characterise the metabolic profile within the bone marrow of healthy donors and patients with MGUS or MM, and to determine if any observed differences between these disorders could be observed within peripheral plasma.
Original languageEnglish
Article numbere359
JournalBlood Cancer Journal
Volume5
DOIs
Publication statusPublished - 16 Oct 2015

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