Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections

JS Im; T-J Kang; S-B Lee; C-H Kim; MM Venkataswamy; E Serfass; PA Chen; Petr Illarionov; Gurdyal Besra; WR Jacobs; G-T Chae; SA Porcelli

doi:10.1016/j.clim.2007.12.005

Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections

JS Im, T-J Kang, S-B Lee, C-H Kim, MM Venkataswamy, E Serfass, PA Chen, Petr Illarionov, Gurdyal Besra, WR Jacobs, G-T Chae, SA Porcelli

Biosciences

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33 Citations (Scopus)

Abstract

CD1d-restricted invariant natural killer T cells (iNKTcells) have been identified as an important type of effector and regulatory T cell., but their roles in the chronic infectious diseases caused by Mycobocterium tuberculosis and Mycobacterium leprae remain poorly defined. Here, we studied circulating human iNKT cells in blood samples from tuberculosis (TB) and leprosy patients. We found that the percentages of iNKT cells among total circulating T cells in TB and leprosy patients were not significantly different from those in normal controls. However, both TB and leprosy patients showed a selective reduction of the proinflammatory CD4(-)CD8 beta(-) (DN) iNKT cells with a proportionate increase in the CD4(+) iNKT cells. Similar phenotypic alterations in circulating iNKT cells were observed in a mouse model of M. tuberculosis infection. Taken together, these findings indicate that the selective reduction of circulating DN iNKT cells is associated with chronic infections caused by M. tuberculosis and M. leprae. (C) 2008 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	214-224
Number of pages	11
Journal	Clin. Immunol
Volume	127
DOIs	https://doi.org/10.1016/j.clim.2007.12.005
Publication status	Published - 1 Jan 2008

Keywords

tuberculosis
mycobacteria
alpha-galactosylceramide
invariant natural killer T cells
leprosy
CD1d
glycolipid

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.clim.2007.12.005

MAGPIE Project: The Structure and Assembly of the Mycobacterial Cell Envelope
Besra, D. (Principal Investigator), Lammas, T. (Co-Investigator) & Minnikin, D. (Co-Investigator)
Medical Research Council
1/02/06 → 31/01/11
Project: Research Councils
Modulation of Immune Responses by aGalCer Analogues Through Differential Activation of CD1d-restricted NKT Cells
Besra, D. (Principal Investigator) & Lammas, T. (Co-Investigator)
Medical Research Council
1/06/05 → 30/11/09
Project: Research Councils

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title = "Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections",

abstract = "CD1d-restricted invariant natural killer T cells (iNKTcells) have been identified as an important type of effector and regulatory T cell., but their roles in the chronic infectious diseases caused by Mycobocterium tuberculosis and Mycobacterium leprae remain poorly defined. Here, we studied circulating human iNKT cells in blood samples from tuberculosis (TB) and leprosy patients. We found that the percentages of iNKT cells among total circulating T cells in TB and leprosy patients were not significantly different from those in normal controls. However, both TB and leprosy patients showed a selective reduction of the proinflammatory CD4(-)CD8 beta(-) (DN) iNKT cells with a proportionate increase in the CD4(+) iNKT cells. Similar phenotypic alterations in circulating iNKT cells were observed in a mouse model of M. tuberculosis infection. Taken together, these findings indicate that the selective reduction of circulating DN iNKT cells is associated with chronic infections caused by M. tuberculosis and M. leprae. (C) 2008 Elsevier Inc. All rights reserved.",

keywords = "tuberculosis, mycobacteria, alpha-galactosylceramide, invariant natural killer T cells, leprosy, CD1d, glycolipid",

author = "JS Im and T-J Kang and S-B Lee and C-H Kim and MM Venkataswamy and E Serfass and PA Chen and Petr Illarionov and Gurdyal Besra and WR Jacobs and G-T Chae and SA Porcelli",

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language = "English",

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T1 - Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections

AU - Im, JS

AU - Kang, T-J

AU - Lee, S-B

AU - Kim, C-H

AU - Venkataswamy, MM

AU - Serfass, E

AU - Chen, PA

AU - Illarionov, Petr

AU - Besra, Gurdyal

AU - Jacobs, WR

AU - Chae, G-T

AU - Porcelli, SA

PY - 2008/1/1

Y1 - 2008/1/1

N2 - CD1d-restricted invariant natural killer T cells (iNKTcells) have been identified as an important type of effector and regulatory T cell., but their roles in the chronic infectious diseases caused by Mycobocterium tuberculosis and Mycobacterium leprae remain poorly defined. Here, we studied circulating human iNKT cells in blood samples from tuberculosis (TB) and leprosy patients. We found that the percentages of iNKT cells among total circulating T cells in TB and leprosy patients were not significantly different from those in normal controls. However, both TB and leprosy patients showed a selective reduction of the proinflammatory CD4(-)CD8 beta(-) (DN) iNKT cells with a proportionate increase in the CD4(+) iNKT cells. Similar phenotypic alterations in circulating iNKT cells were observed in a mouse model of M. tuberculosis infection. Taken together, these findings indicate that the selective reduction of circulating DN iNKT cells is associated with chronic infections caused by M. tuberculosis and M. leprae. (C) 2008 Elsevier Inc. All rights reserved.

AB - CD1d-restricted invariant natural killer T cells (iNKTcells) have been identified as an important type of effector and regulatory T cell., but their roles in the chronic infectious diseases caused by Mycobocterium tuberculosis and Mycobacterium leprae remain poorly defined. Here, we studied circulating human iNKT cells in blood samples from tuberculosis (TB) and leprosy patients. We found that the percentages of iNKT cells among total circulating T cells in TB and leprosy patients were not significantly different from those in normal controls. However, both TB and leprosy patients showed a selective reduction of the proinflammatory CD4(-)CD8 beta(-) (DN) iNKT cells with a proportionate increase in the CD4(+) iNKT cells. Similar phenotypic alterations in circulating iNKT cells were observed in a mouse model of M. tuberculosis infection. Taken together, these findings indicate that the selective reduction of circulating DN iNKT cells is associated with chronic infections caused by M. tuberculosis and M. leprae. (C) 2008 Elsevier Inc. All rights reserved.

KW - tuberculosis

KW - mycobacteria

KW - alpha-galactosylceramide

KW - invariant natural killer T cells

KW - leprosy

KW - CD1d

KW - glycolipid

U2 - 10.1016/j.clim.2007.12.005

DO - 10.1016/j.clim.2007.12.005

M3 - Article

C2 - 18308638

VL - 127

SP - 214

EP - 224

JO - Clin. Immunol

JF - Clin. Immunol

ER -

Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections

Abstract

Keywords

UN SDGs

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Projects

MAGPIE Project: The Structure and Assembly of the Mycobacterial Cell Envelope

Modulation of Immune Responses by aGalCer Analogues Through Differential Activation of CD1d-restricted NKT Cells

Cite this