Alpha cell function in type 1 diabetes

David Simon Hughes, Parth Narendran

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)


Our understanding of the pathogenesis of type 1 diabetes mellitus has traditionally revolved around the insulin deficiency that follows pancreatic beta cell loss. However, there is an increasing appreciation of defects in other gluco-regulatory cells in type 1 diabetes mellitus. Oversecretion of glucagon from pancreatic alpha cells is characteristic of type 1 diabetes mellitus, and modulating these glucagon levels reduces hyperglycaemia. This article reviews alpha cell function in type 1 diabetes mellitus. We examine how its function is controlled and compromised, and review studies that target alpha cell function. Finally, we explore potential approaches to modulating alpha cell function in type 1 diabetes mellitus.
Original languageEnglish
Pages (from-to)45-51
Number of pages7
JournalThe British Journal of Diabetes & Vascular Disease
Issue number2
Publication statusPublished - Apr 2014


  • alpha cell
  • glucagon
  • siabetes
  • type 1
  • Islets of Langerhans
  • DPP-4
  • GLP-1
  • insulin


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