Allistatin: A potent yet uncharacterized therapeutic nugget in Allium sativum

Timothy Prince Chidike Ezeorba*, Chinonso Anthony Ezema*, Rita Onyekachukwu Asomadu*, Christian Chiazor Chibuogwu, Wisdom Favour Chinedu Ezeorba, Chinenye Patience Ezeorba, Parker Elijah Joshua

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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Abstract

Major solutions to human health challenges are encrypted in nature's resources. Despite the focus of contemporary research on characterizing plant natural products and phytochemicals, a vast number of plants are yet to be discovered, or their products functionally characterized. Garlic is one of the most common traditional Chinese medicinal plants and a hub of over 200 diverse phytochemicals. Interestingly, allistatin is a phytochemical frequently mentioned alongside allicin in research articles on Garlic (Allium sativum) and has been reported to possess interesting therapeutic activities. However, there are no reports on the proper characterization of allistatin or any of its structural information available on public repositories or databases. Moreover, experimental evidence to back up the claims of its therapeutic bioactivities is not available in any accessible literature. All of these have hampered prospective studies with allistatin and possible discoveries of novel therapeutic activities. This review provides a piece of up-to-date information on allistatin and a hypothetical prediction of the nature of its structure from the sparsely available information. Available information on its bioactivities was also reviewed, although very sparse evidence on their mechanism of action. Finally, a pathway towards the complete characterization of allistatin was suggested as a future prospect.

Original languageEnglish
Article number100121
Number of pages5
JournalPharmacological Research - Modern Chinese Medicine
Volume3
Early online date31 May 2022
DOIs
Publication statusPublished - Jun 2022

Bibliographical note

Publisher Copyright:
© 2022 The Author(s)

Keywords

  • Allicin
  • Allistatin
  • Allium sativum
  • Characterization
  • Cyanidin
  • Garlicin
  • Quercetin
  • Therapeutic

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • Complementary and alternative medicine
  • Pharmacology (medical)

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