Alcohol sensitivity, alcohol use and hypertension in an older Chinese population: the Guangzhou Biobank Cohort Study

WS Zhang, CQ Jiang, Kar Cheng, Peymane Adab, Graham Thomas, B Liu, Kin Bong Hubert Lam, CM Schooling, TH Lam

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10 Citations (Scopus)

Abstract

Although the J-shaped association between alcohol consumption and blood pressure ( BP) is well known, the effect of alcohol sensitivity on this relationship is less clear. We studied the association of alcohol sensitivity and alcohol use with BP and hypertension. This cross-sectional analysis included 19 335 older participants from the Guangzhou Biobank Cohort Study recruited from 2003 to 2006, using clinically measured BP and self-reported alcohol use and alcohol sensitivity. Alcohol use was rare in women, in whom light-to-moderate drinkers (= 140 g ethanol per week) without alcohol sensitivity had a significantly higher systolic and diastolic BP and risk of hypertension than did nondrinkers ( mean difference 5.1 (2.8-7.4) mmHg, 2.7 (1.5-4.0) mmHg and 34% (8-66%), respectively, for men). These differences were even greater for men with alcohol sensitivity ( mean differences 12.0 (8.9-15.2) mmHg, 6.2 (4.5-7.9) mmHg and 95% CI (46-159%), respectively). Alcohol sensitivity and alcohol use were both associated with elevated BP and risk of hypertension in an older Chinese population. Alcohol sensitivity may aggravate the effect of drinking on BP. Limiting alcohol use to two drinks per day for men and one drink a day for women may be suitable for East Asians. Reduction of alcohol consumption should be an important public health target. Hypertension Research (2009) 32, 741-747; doi: 10.1038/hr.2009.92; published online 26 June 2009
Original languageEnglish
Pages (from-to)741-747
Number of pages7
JournalHypertension Research
Volume32
Issue number9
DOIs
Publication statusPublished - 1 Sep 2009

Keywords

  • blood pressure
  • alcohol use
  • alcohol sensitivity
  • Chinese

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