A[H1N1] flu and refractory hypoxaemia: is extracorporeal lung support the holy grail?

T V Veenith; M Rana; A Ercole; K Gunning; R Mahroof

doi:10.1136/thoraxjnl-2011-200092

A[H1N1] flu and refractory hypoxaemia: is extracorporeal lung support the holy grail?

T V Veenith, M Rana, A Ercole, K Gunning, R Mahroof

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

There is a call for methodologically robust randomised clinical trials in adult extracorporeal membrane oxygenation for its routine implementation for patients with "failing" conventional ventilation. Adherence to lung protective ventilation strategies, along with fluid balance [if required early renal replacement therapy] and inotropes to support the circulation to minimise ventilator-induced lung injury, may mitigate deterioration requiring extracorporeal lung support. Currently there is no convincing evidence to routinely advocate extracorporeal lung support in failed conventional ventilation, and a prospective trial is needed to define standard best practice and to tailor extracorporeal lung support referral criteria in young patient cohort with severe refractory respiratory failure.

Original language	English
Pages (from-to)	836-7
Number of pages	2
Journal	Thorax
Volume	66
Issue number	9
DOIs	https://doi.org/10.1136/thoraxjnl-2011-200092
Publication status	Published - Sept 2011

Keywords

Adolescent
Adult
Extracorporeal Membrane Oxygenation/methods
Female
Follow-Up Studies
Humans
Hypoxia/complications
Influenza A Virus, H1N1 Subtype/isolation & purification
Influenza, Human/complications
Male
Middle Aged
Positive-Pressure Respiration/methods
Prospective Studies
Respiratory Insufficiency/etiology
Treatment Outcome
Young Adult

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10.1136/thoraxjnl-2011-200092

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title = "A[H1N1] flu and refractory hypoxaemia: is extracorporeal lung support the holy grail?",

abstract = "There is a call for methodologically robust randomised clinical trials in adult extracorporeal membrane oxygenation for its routine implementation for patients with {"}failing{"} conventional ventilation. Adherence to lung protective ventilation strategies, along with fluid balance [if required early renal replacement therapy] and inotropes to support the circulation to minimise ventilator-induced lung injury, may mitigate deterioration requiring extracorporeal lung support. Currently there is no convincing evidence to routinely advocate extracorporeal lung support in failed conventional ventilation, and a prospective trial is needed to define standard best practice and to tailor extracorporeal lung support referral criteria in young patient cohort with severe refractory respiratory failure.",

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author = "Veenith, {T V} and M Rana and A Ercole and K Gunning and R Mahroof",

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AU - Rana, M

AU - Ercole, A

AU - Gunning, K

AU - Mahroof, R

PY - 2011/9

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AB - There is a call for methodologically robust randomised clinical trials in adult extracorporeal membrane oxygenation for its routine implementation for patients with "failing" conventional ventilation. Adherence to lung protective ventilation strategies, along with fluid balance [if required early renal replacement therapy] and inotropes to support the circulation to minimise ventilator-induced lung injury, may mitigate deterioration requiring extracorporeal lung support. Currently there is no convincing evidence to routinely advocate extracorporeal lung support in failed conventional ventilation, and a prospective trial is needed to define standard best practice and to tailor extracorporeal lung support referral criteria in young patient cohort with severe refractory respiratory failure.

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KW - Adult

KW - Extracorporeal Membrane Oxygenation/methods

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Hypoxia/complications

KW - Influenza A Virus, H1N1 Subtype/isolation & purification

KW - Influenza, Human/complications

KW - Male

KW - Middle Aged

KW - Positive-Pressure Respiration/methods

KW - Prospective Studies

KW - Respiratory Insufficiency/etiology

KW - Treatment Outcome

KW - Young Adult

U2 - 10.1136/thoraxjnl-2011-200092

DO - 10.1136/thoraxjnl-2011-200092

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JO - Thorax

JF - Thorax

IS - 9

ER -

A[H1N1] flu and refractory hypoxaemia: is extracorporeal lung support the holy grail?

Abstract

Keywords

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