Ageing with Interstitial lung disease: Preserving health and well being

Lesley Ann Saketkoo; Ogugua Ndili Obi; Karen C. Patterson; Anne Marie Russell

doi:10.1097/MCP.0000000000000880

Ageing with Interstitial lung disease: Preserving health and well being

Lesley Ann Saketkoo^*, Ogugua Ndili Obi, Karen C. Patterson, Anne Marie Russell

^*Corresponding author for this work

Nursing and Midwifery

Research output: Contribution to journal › Review article › peer-review

Abstract

Purpose of review: Ageing, the accrual of molecular and cellular damage over a lifetime confers progressive physiologic dysfunction of bodily systems, leaving the body in a heightened state of vulnerability to biophysical and psychosocial stressors. The inflection point is frailty which easily leads to disability and death. Interstitial lung disease (ILD) creates biophysical and psychosocial stresses difficult for even optimally fit patients to cope with. With evolving ILD treatment pathways, people with ILD are living longer.

Recent findings: ILD and ageing are bi-directionally influential: ILD, its treatments, complications, and collateral systemic extra-pulmonary damage (hypoxic and oxidative stress) wear on the ageing person and ageing impacts a person's tolerance of ILD. ILD extent may proportionally accelerate age-related vulnerabilities. ILD related to inflammatory systemic diseases, e.g. connective tissue diseases or sarcoidosis, exert an even more complex biophysical impact on the body.

Summary: The present review stresses goals of preventing frailty in ILD and preserving general health and well being of people living with ILD of any age, from time of diagnosis and as they age. The development of a prediction score is proposed to classify those at risk of frailty and guide interventions that preserve successful ageing for all levels of ILD severity.

http://links.lww.com/COPM/A32.

Original language	English
Pages (from-to)	321-336
Number of pages	16
Journal	Current Opinion in Pulmonary Medicine
Volume	28
Issue number	4
DOIs	https://doi.org/10.1097/MCP.0000000000000880
Publication status	Published - 31 Jul 2022

Bibliographical note

Funding Information:
L.A.S. has received funding and research support from Charles and Elizabeth Wetmore Foundation of Greater New Orleans, and Sarcoidosis Awareness Foundation of Louisiana (SAFOL), Scleroderma Foundation, Federation of European Scleroderma Associations (FESCA), Sarcoidosis UK, Scleroderma and Raynauds Society UK (SRUK).

Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.

Keywords

ageing
cachexia
frailty
health-related quality of life
interstitial lung disease
sarcopenia

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

Access to Document

10.1097/MCP.0000000000000880

Cite this

@article{9424f243c65346dfa8ffde16096ec709,

title = "Ageing with Interstitial lung disease: Preserving health and well being",

abstract = "Purpose of review: Ageing, the accrual of molecular and cellular damage over a lifetime confers progressive physiologic dysfunction of bodily systems, leaving the body in a heightened state of vulnerability to biophysical and psychosocial stressors. The inflection point is frailty which easily leads to disability and death. Interstitial lung disease (ILD) creates biophysical and psychosocial stresses difficult for even optimally fit patients to cope with. With evolving ILD treatment pathways, people with ILD are living longer.Recent findings: ILD and ageing are bi-directionally influential: ILD, its treatments, complications, and collateral systemic extra-pulmonary damage (hypoxic and oxidative stress) wear on the ageing person and ageing impacts a person's tolerance of ILD. ILD extent may proportionally accelerate age-related vulnerabilities. ILD related to inflammatory systemic diseases, e.g. connective tissue diseases or sarcoidosis, exert an even more complex biophysical impact on the body.Summary: The present review stresses goals of preventing frailty in ILD and preserving general health and well being of people living with ILD of any age, from time of diagnosis and as they age. The development of a prediction score is proposed to classify those at risk of frailty and guide interventions that preserve successful ageing for all levels of ILD severity.http://links.lww.com/COPM/A32.",

keywords = "ageing, cachexia, frailty, health-related quality of life, interstitial lung disease, sarcopenia",

author = "Saketkoo, {Lesley Ann} and Obi, {Ogugua Ndili} and Patterson, {Karen C.} and Russell, {Anne Marie}",

note = "Funding Information: L.A.S. has received funding and research support from Charles and Elizabeth Wetmore Foundation of Greater New Orleans, and Sarcoidosis Awareness Foundation of Louisiana (SAFOL), Scleroderma Foundation, Federation of European Scleroderma Associations (FESCA), Sarcoidosis UK, Scleroderma and Raynauds Society UK (SRUK). Publisher Copyright: {\textcopyright} 2022 Lippincott Williams and Wilkins. All rights reserved.",

year = "2022",

month = jul,

day = "31",

doi = "10.1097/MCP.0000000000000880",

language = "English",

volume = "28",

pages = "321--336",

journal = "Current Opinion in Pulmonary Medicine",

issn = "1070-5287",

publisher = "Lippincott Williams and Wilkins",

number = "4",

}

TY - JOUR

T1 - Ageing with Interstitial lung disease

T2 - Preserving health and well being

AU - Saketkoo, Lesley Ann

AU - Obi, Ogugua Ndili

AU - Patterson, Karen C.

AU - Russell, Anne Marie

N1 - Funding Information: L.A.S. has received funding and research support from Charles and Elizabeth Wetmore Foundation of Greater New Orleans, and Sarcoidosis Awareness Foundation of Louisiana (SAFOL), Scleroderma Foundation, Federation of European Scleroderma Associations (FESCA), Sarcoidosis UK, Scleroderma and Raynauds Society UK (SRUK). Publisher Copyright: © 2022 Lippincott Williams and Wilkins. All rights reserved.

PY - 2022/7/31

Y1 - 2022/7/31

N2 - Purpose of review: Ageing, the accrual of molecular and cellular damage over a lifetime confers progressive physiologic dysfunction of bodily systems, leaving the body in a heightened state of vulnerability to biophysical and psychosocial stressors. The inflection point is frailty which easily leads to disability and death. Interstitial lung disease (ILD) creates biophysical and psychosocial stresses difficult for even optimally fit patients to cope with. With evolving ILD treatment pathways, people with ILD are living longer.Recent findings: ILD and ageing are bi-directionally influential: ILD, its treatments, complications, and collateral systemic extra-pulmonary damage (hypoxic and oxidative stress) wear on the ageing person and ageing impacts a person's tolerance of ILD. ILD extent may proportionally accelerate age-related vulnerabilities. ILD related to inflammatory systemic diseases, e.g. connective tissue diseases or sarcoidosis, exert an even more complex biophysical impact on the body.Summary: The present review stresses goals of preventing frailty in ILD and preserving general health and well being of people living with ILD of any age, from time of diagnosis and as they age. The development of a prediction score is proposed to classify those at risk of frailty and guide interventions that preserve successful ageing for all levels of ILD severity.http://links.lww.com/COPM/A32.

AB - Purpose of review: Ageing, the accrual of molecular and cellular damage over a lifetime confers progressive physiologic dysfunction of bodily systems, leaving the body in a heightened state of vulnerability to biophysical and psychosocial stressors. The inflection point is frailty which easily leads to disability and death. Interstitial lung disease (ILD) creates biophysical and psychosocial stresses difficult for even optimally fit patients to cope with. With evolving ILD treatment pathways, people with ILD are living longer.Recent findings: ILD and ageing are bi-directionally influential: ILD, its treatments, complications, and collateral systemic extra-pulmonary damage (hypoxic and oxidative stress) wear on the ageing person and ageing impacts a person's tolerance of ILD. ILD extent may proportionally accelerate age-related vulnerabilities. ILD related to inflammatory systemic diseases, e.g. connective tissue diseases or sarcoidosis, exert an even more complex biophysical impact on the body.Summary: The present review stresses goals of preventing frailty in ILD and preserving general health and well being of people living with ILD of any age, from time of diagnosis and as they age. The development of a prediction score is proposed to classify those at risk of frailty and guide interventions that preserve successful ageing for all levels of ILD severity.http://links.lww.com/COPM/A32.

KW - ageing

KW - cachexia

KW - frailty

KW - health-related quality of life

KW - interstitial lung disease

KW - sarcopenia

UR - http://www.scopus.com/inward/record.url?scp=85133102356&partnerID=8YFLogxK

U2 - 10.1097/MCP.0000000000000880

DO - 10.1097/MCP.0000000000000880

M3 - Review article

C2 - 35749798

AN - SCOPUS:85133102356

SN - 1070-5287

VL - 28

SP - 321

EP - 336

JO - Current Opinion in Pulmonary Medicine

JF - Current Opinion in Pulmonary Medicine

IS - 4

ER -

Ageing with Interstitial lung disease: Preserving health and well being

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this