Abstract
OBJECTIVE: To determine the age-related risk of hepatotoxicity under currently recommended treatment regimens for latent tuberculosis (TB) infection (LTBI).
METHODS: A systematic review of the MEDLINE and EMBASE databases (from database inception to 2008) was performed to determine the risk of isoniazid (INH) and/or rifampicin hepatotoxicity in LTBI treatment stratified by patient age. Study selection, study quality assessment and data extraction were performed using piloted proformas. Rate data were meta-analysed to generate summary rates with 95%CI within age-related subgroups using a random effects model.
RESULTS: Seven relevant studies (18 610 participants, including 115 cases of hepatotoxicity) met the selection criteria. The median rate of hepatotoxicity was 1.8% (range 0.07-11.9). On average, rates were higher among those aged >= 35 years (1.7%, 95%CI 1.4-2.2) than those aged
| Original language | English |
|---|---|
| Pages (from-to) | 1374-1381 |
| Number of pages | 8 |
| Journal | International Journal of Tuberculosis and Lung Disease (IJTLD) |
| Volume | 14 |
| Issue number | 11 |
| Publication status | Published - 1 Nov 2010 |
Keywords
- tuberculosis
- isoniazid
- hepatotoxicity
- systematic review
