Age at menarche and depressive symptoms in older Southern Chinese women:: A Mendelian randomization study in the Guangzhou Biobank Cohort Study

Shiu Lun Au Yeung; Chaoqiang Jiang; Kar Keung Cheng; Lin Xu; Weisen Zhang; Tai Hing Lam; Gabriel Matthew Leung; C. Mary Schooling

doi:10.1016/j.psychres.2017.09.040

Age at menarche and depressive symptoms in older Southern Chinese women: A Mendelian randomization study in the Guangzhou Biobank Cohort Study

Shiu Lun Au Yeung, Chaoqiang Jiang, Kar Keung Cheng, Lin Xu, Weisen Zhang, Tai Hing Lam, Gabriel Matthew Leung, C. Mary Schooling

Applied Health Sciences

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Abstract

To clarify the causal role of age at menarche in depressive symptoms we conducted a Mendelian randomization study using a large Southern Chinese cohort (n=12,233). A genetic allele score was derived using stepwise regression with cross validation. Older age at menarche was not associated with geriatric depression scale score. Our findings suggest that higher rates of depression in women are likely attributable to other factors which require investigation.

Original language	English
Journal	Psychiatry Research
Early online date	19 Sept 2017
DOIs	https://doi.org/10.1016/j.psychres.2017.09.040
Publication status	E-pub ahead of print - 19 Sept 2017

Keywords

China
epidemiology

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Yeung_et_al_Age_at_menarche_and_depressive_symptoms_Psychiatry_Research_2017Accepted author manuscript, 614 KBLicence: Creative Commons: Attribution-NonCommercial-NoDerivs (CC BY-NC-ND)

http://www.sciencedirect.com/science/article/pii/S0165178117300987Licence: None: All rights reserved

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title = "Age at menarche and depressive symptoms in older Southern Chinese women:: A Mendelian randomization study in the Guangzhou Biobank Cohort Study",

abstract = "To clarify the causal role of age at menarche in depressive symptoms we conducted a Mendelian randomization study using a large Southern Chinese cohort (n=12,233). A genetic allele score was derived using stepwise regression with cross validation. Older age at menarche was not associated with geriatric depression scale score. Our findings suggest that higher rates of depression in women are likely attributable to other factors which require investigation.",

keywords = "China , epidemiology",

author = "Yeung, {Shiu Lun Au} and Chaoqiang Jiang and Cheng, {Kar Keung} and Lin Xu and Weisen Zhang and Lam, {Tai Hing} and Leung, {Gabriel Matthew} and Schooling, {C. Mary}",

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T1 - Age at menarche and depressive symptoms in older Southern Chinese women:

T2 - A Mendelian randomization study in the Guangzhou Biobank Cohort Study

AU - Yeung, Shiu Lun Au

AU - Jiang, Chaoqiang

AU - Cheng, Kar Keung

AU - Xu, Lin

AU - Zhang, Weisen

AU - Lam, Tai Hing

AU - Leung, Gabriel Matthew

AU - Schooling, C. Mary

PY - 2017/9/19

Y1 - 2017/9/19

N2 - To clarify the causal role of age at menarche in depressive symptoms we conducted a Mendelian randomization study using a large Southern Chinese cohort (n=12,233). A genetic allele score was derived using stepwise regression with cross validation. Older age at menarche was not associated with geriatric depression scale score. Our findings suggest that higher rates of depression in women are likely attributable to other factors which require investigation.

AB - To clarify the causal role of age at menarche in depressive symptoms we conducted a Mendelian randomization study using a large Southern Chinese cohort (n=12,233). A genetic allele score was derived using stepwise regression with cross validation. Older age at menarche was not associated with geriatric depression scale score. Our findings suggest that higher rates of depression in women are likely attributable to other factors which require investigation.

KW - China

KW - epidemiology

U2 - 10.1016/j.psychres.2017.09.040

DO - 10.1016/j.psychres.2017.09.040

M3 - Article

SN - 0165-1781

JO - Psychiatry Research

JF - Psychiatry Research

ER -

Age at menarche and depressive symptoms in older Southern Chinese women: A Mendelian randomization study in the Guangzhou Biobank Cohort Study

Abstract

Keywords

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