Advances in keratinocyte delivery in burn wound care

Britt Ter Horst, Gurpreet Chouhan, Naiem S. Moiemen, Liam M. Grover

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65 Citations (Scopus)
290 Downloads (Pure)

Abstract

This review gives an updated overview on keratinocyte transplantation in burn wounds concentrating on application methods and future therapeutic cell delivery options with a special interest in hydrogels and spray devices for cell delivery.

To achieve faster re-epithelialisation of burn wounds, the original autologous keratinocyte culture and transplantation technique was introduced over 3 decades ago. Application types of keratinocytes transplantation have improved from cell sheets to single-cell solutions delivered with a spray system. However, further enhancement of cell culture, cell viability and function in vivo, cell carrier and cell delivery systems remain themes of interest.

Hydrogels such as chitosan, alginate, fibrin and collagen are frequently used in burn wound care and have advantageous characteristics as cell carriers.

Future approaches of keratinocyte transplantation involve spray devices, but optimisation of application technique and carrier type is necessary.
Original languageEnglish
Pages (from-to)18-32
JournalAdvanced Drug Delivery Reviews
Volume123
Early online date28 Jun 2017
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • cell transplantation
  • burn injury
  • wound healing
  • hydrogels
  • spray application

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