TY - JOUR
T1 - Advanced tools for the safety assessment of nanomaterials
AU - Fadeel, Bengt
AU - Farcal, Lucian
AU - Hardy, Barry J.
AU - Vázquez-Campos, Socorro
AU - Hristozov, Danail
AU - Marcomini, Antonio
AU - Lynch, Iseult
AU - Valsami-Jones, Eugenia
AU - Alenius, Harri
AU - Savolainen, Kai
PY - 2018/7/6
Y1 - 2018/7/6
N2 - Engineered nanomaterials (ENMs) have tremendous potential to produce beneficial technological impact in numerous sectors in society. Safety assessment is, of course, of paramount importance. However, the myriad variations of ENM properties makes the identification of specific features driving toxicity challenging. At the same time, reducing animal tests by introducing alternative and/or predictive in vitro and in silico methods has become a priority. It is important to embrace these new advances in the safety assessment of ENMs. Indeed, remarkable progress has been made in recent years with respect to mechanism-based hazard assessment of ENMs, including systems biology approaches as well as high-throughput screening platforms, and new tools are also emerging in risk assessment and risk management for humans and the environment across the whole life-cycle of nano-enabled products. Here, we highlight some of the key advances in the hazard and risk assessment of ENMs.
AB - Engineered nanomaterials (ENMs) have tremendous potential to produce beneficial technological impact in numerous sectors in society. Safety assessment is, of course, of paramount importance. However, the myriad variations of ENM properties makes the identification of specific features driving toxicity challenging. At the same time, reducing animal tests by introducing alternative and/or predictive in vitro and in silico methods has become a priority. It is important to embrace these new advances in the safety assessment of ENMs. Indeed, remarkable progress has been made in recent years with respect to mechanism-based hazard assessment of ENMs, including systems biology approaches as well as high-throughput screening platforms, and new tools are also emerging in risk assessment and risk management for humans and the environment across the whole life-cycle of nano-enabled products. Here, we highlight some of the key advances in the hazard and risk assessment of ENMs.
KW - Nanoscale materials
KW - Nanotoxicology
U2 - 10.1038/s41565-018-0185-0
DO - 10.1038/s41565-018-0185-0
M3 - Review article
C2 - 29980781
SN - 1748-3387
VL - 13
SP - 537
EP - 543
JO - Nature Nanotechnology
JF - Nature Nanotechnology
IS - 7
ER -