Adrenal Corticosteroid Biosynthesis, Metabolism, and Action

Wiebke Arlt; Paul Stewart

doi:10.1016/j.ecl.2005.01.002

Adrenal Corticosteroid Biosynthesis, Metabolism, and Action

Wiebke Arlt, Paul Stewart

Medical and Dental Sciences

Research output: Contribution to journal › Review article

105 Citations (Scopus)

Abstract

Adrenal corticosteroids are essential for life, and an appreciation of the mechanisms underpinning their synthesis, secretion, and mode of action in normal physiology is essential if the physician is to diagnose and treat patients who have Cushing's syndromes effectively. In each case, there have been clinically significant advances in the knowledge base over recent years, notably in the understanding of steroidogenesis, cortisol action, and metabolism. This article describes corticosteroid biosynthesis, metabolism, and action.

Original language	English
Pages (from-to)	293-313
Number of pages	21
Journal	Endocrinology and Metabolism Clinics of North America
Volume	34
Issue number	2
DOIs	https://doi.org/10.1016/j.ecl.2005.01.002
Publication status	Published - 1 Jun 2005

Access to Document

10.1016/j.ecl.2005.01.002

Pre-Receptor Regulation of Dehydroepiandrosterone Synthesis, Metabolism and Action
Arlt, W.
Medical Research Council
1/08/04 → 31/10/09
Project: Research Councils

Cite this

@article{fd2f7b58028a409180e9b809de95d7fc,

title = "Adrenal Corticosteroid Biosynthesis, Metabolism, and Action",

abstract = "Adrenal corticosteroids are essential for life, and an appreciation of the mechanisms underpinning their synthesis, secretion, and mode of action in normal physiology is essential if the physician is to diagnose and treat patients who have Cushing's syndromes effectively. In each case, there have been clinically significant advances in the knowledge base over recent years, notably in the understanding of steroidogenesis, cortisol action, and metabolism. This article describes corticosteroid biosynthesis, metabolism, and action.",

author = "Wiebke Arlt and Paul Stewart",

year = "2005",

month = jun,

day = "1",

doi = "10.1016/j.ecl.2005.01.002",

language = "English",

volume = "34",

pages = "293--313",

journal = "Endocrinology and Metabolism Clinics of North America",

issn = "1558-4410",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Adrenal Corticosteroid Biosynthesis, Metabolism, and Action

AU - Arlt, Wiebke

AU - Stewart, Paul

PY - 2005/6/1

Y1 - 2005/6/1

N2 - Adrenal corticosteroids are essential for life, and an appreciation of the mechanisms underpinning their synthesis, secretion, and mode of action in normal physiology is essential if the physician is to diagnose and treat patients who have Cushing's syndromes effectively. In each case, there have been clinically significant advances in the knowledge base over recent years, notably in the understanding of steroidogenesis, cortisol action, and metabolism. This article describes corticosteroid biosynthesis, metabolism, and action.

AB - Adrenal corticosteroids are essential for life, and an appreciation of the mechanisms underpinning their synthesis, secretion, and mode of action in normal physiology is essential if the physician is to diagnose and treat patients who have Cushing's syndromes effectively. In each case, there have been clinically significant advances in the knowledge base over recent years, notably in the understanding of steroidogenesis, cortisol action, and metabolism. This article describes corticosteroid biosynthesis, metabolism, and action.

UR - http://www.scopus.com/inward/record.url?scp=18044391471&partnerID=8YFLogxK

U2 - 10.1016/j.ecl.2005.01.002

DO - 10.1016/j.ecl.2005.01.002

M3 - Review article

C2 - 15850843

SN - 1558-4410

VL - 34

SP - 293

EP - 313

JO - Endocrinology and Metabolism Clinics of North America

JF - Endocrinology and Metabolism Clinics of North America

IS - 2

ER -

Adrenal Corticosteroid Biosynthesis, Metabolism, and Action

Abstract

Access to Document

Fingerprint

Projects

Pre-Receptor Regulation of Dehydroepiandrosterone Synthesis, Metabolism and Action

Cite this