Adrenal Corticosteroid Biosynthesis, Metabolism, and Action

Wiebke Arlt, Paul Stewart

Research output: Contribution to journalReview article

105 Citations (Scopus)


Adrenal corticosteroids are essential for life, and an appreciation of the mechanisms underpinning their synthesis, secretion, and mode of action in normal physiology is essential if the physician is to diagnose and treat patients who have Cushing's syndromes effectively. In each case, there have been clinically significant advances in the knowledge base over recent years, notably in the understanding of steroidogenesis, cortisol action, and metabolism. This article describes corticosteroid biosynthesis, metabolism, and action.
Original languageEnglish
Pages (from-to)293-313
Number of pages21
JournalEndocrinology and Metabolism Clinics of North America
Issue number2
Publication statusPublished - 1 Jun 2005


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