Adoptive cellular therapy for early cytomegalovirus infection after allogeneic stem-cell transplantation with virus-specific T-cell lines

KS Peggs, S Verfuerth, A Pizzey, Naeem Khan, M Guiver, Paul Moss, S Mackinnon

Research output: Contribution to journalArticle

378 Citations (Scopus)

Abstract

Adoptive transfer of CMV-specific T cells offers the potential for reconstitution of viral immunity after allogeneic transplantation. However, the logistics of producing virus-specific T-cell clones has limited the application of cellular therapies. We treated 16 patients for CMV infection with polyclonal CMV-specific T-cell lines generated by short-term culture. Massive in-vivo expansions of CMV-specific cytotoxic T lymphocytes were observed, resulting in reconstitution of viral immunity. In eight cases antiviral drugs were not required, and subsequent episodes of reactivation occurred in only two patients. Our findings indicate that application of CMV-specific cell lines is both feasible and effective in a clinical environment.
Original languageEnglish
Pages (from-to)1375-1377
Number of pages3
JournalLancet
Volume362
Issue number9393
DOIs
Publication statusPublished - 25 Oct 2003

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