Adjuvant properties of a simplified C32 monomycolyl glycerol analogue

Veemal Bhowruth, David Minnikin, EM Agger, P Andersen, VW Bramwell, Y Perrie, Gurdyal Besra

Research output: Contribution to journalArticle

19 Citations (Scopus)


A simplified C(32) monomycolyl glycerol (MMG) analogue demonstrated enhanced immunostimulatory activity in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation. Elevated levels of IFN-gamma and IL-6 were produced in spleen cells from mice immunised with a C(32) MMG analogue comparable activity to the potent Th1 adjuvant, trehalose 6,6'-di-behenate (TDB).
Original languageEnglish
Pages (from-to)2029-32
Number of pages4
JournalBioorganic & Medicinal Chemistry Letters
Issue number7
Publication statusPublished - 1 Apr 2009


  • Adjuvant
  • Monomycolyl glycerol
  • Vaccine
  • Tuberculosis
  • Ag85B-ESAT-6


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